| Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions | |
Zhu JC(朱婧辰)1,2,3; Chen SB(陈深宝)1,2,3 ; Zhou LW(周吕文)1,2,3,4; Gong, Xiaobo5; Cui, Yuhong6; Zhang Y(章燕)1,2,3; Long M(龙勉)1,2,3; Lv SQ(吕守芹)1,2,3
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| Corresponding Author | Long, Mian([email protected]) ; Lu, Shouqin([email protected]) |
| Source Publication | BIOPHYSICAL JOURNAL
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| 2025-02-04 | |
| Volume | 124Issue:3Pages:480-493 |
| ISSN | 0006-3495 |
| Abstract | It is interesting to find pathologically that leukocytes, especially neutrophils, tend to adhere in the liver sinusoids dominantly but not in the postsinusoidal venules. While both views of receptor-ligand interactions and physical trapping are proposed for mediating leukocyte adhesion in liver sinusoids, integrated investigations for classifying their respective contributions are poorly presented. With a combination of Monte Carlo simulation and immersed boundary method, this study explored numerically the effects of molecular interaction kinetics and sinusoidal mechanical properties on leukocyte adhesion in liver sinusoid jointly. Results showed that, within the range of biological limitations, the lumen stenosis ratio, leukocyte stiffness, Disse space stiffness and endothelium permeability regulate the comprehensive adhesion process in a descending order of significance in the presence of receptor-ligand interactions. While leukocyte adhesions could be mutually promoted with proper combinations of leukocyte stiffness, lumen stenosis, and molecular interaction, the binding affinity is insensitive under the conditions with low leukocyte stiffness in normal lumen stenosis and high leukocyte stiffness in high lumen stenosis. This work deepens the understanding of recruitment mechanism of leukocyte in liver sinusoids. |
| DOI | 10.1016/j.bpj.2024.11.3315 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:001422868800001 |
| WOS Keyword | HEPATIC MICROCIRCULATION ; P-SELECTIN ; CELL ; SIMULATION ; FLOW ; DEFORMABILITY ; RECRUITMENT ; DYNAMICS ; NEUTROPHILS ; HYALURONAN |
| WOS Research Area | Biophysics |
| WOS Subject | Biophysics |
| Funding Project | National Natural Science Foundation of China[T2394512] ; National Natural Science Foundation of China[32130061] ; National Natural Science Foundation of China[12172366] ; National Natural Science Foundation of China[12072198] ; Scientific Instrument Developing Project of Chinese Academy of Sciences[GJJSTD20220002] |
| Funding Organization | National Natural Science Foundation of China ; Scientific Instrument Developing Project of Chinese Academy of Sciences |
| Classification | 一类/力学重要期刊 |
| Ranking | 1 |
| Contributor | 龙勉 ; 吕守芹 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/100120 |
| Collection | 微重力重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Mech, Ctr Biomech & Bioengn, Key Lab Micrograv,Natl Micrograv Lab,Beijing Key L, Beijing, Peoples R China; 2.Chinese Acad Sci, Inst Mech, CAS Ctr Excellence Complex Syst Mech, Beijing, Peoples R China; 3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China; 4.Ningbo Univ, Sch Mech Engn & Mech, Smart Mat & Adv Struct Lab, Ningbo, Zhejiang, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Naval Architecture Ocean & Civil Engn, Dept Engn Mech, Key Lab Hydrodynam,Minist Educ, Shanghai, Peoples R China; 6.Tianjin Univ, Dept Mech, Tianjin, Peoples R China |
| Recommended Citation GB/T 7714 | Zhu JC,Chen SB,Zhou LW,et al. Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions[J]. BIOPHYSICAL JOURNAL,2025,124,3,:480-493.Rp_Au:龙勉, 吕守芹 |
| APA | 朱婧辰.,陈深宝.,周吕文.,Gong, Xiaobo.,Cui, Yuhong.,...&吕守芹.(2025).Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions.BIOPHYSICAL JOURNAL,124(3),480-493. |
| MLA | 朱婧辰,et al."Effects of molecular interaction and liver sinusoidal mechanical properties on leukocyte adhesions".BIOPHYSICAL JOURNAL 124.3(2025):480-493. |
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