Knowledge Management System of Institue of Mechanics, CAS
| The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium | |
Li AL; Li HW; Jin G(靳刚) ; Xiu RJ
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| Source Publication | CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2003,29(3-4):375-382 |
| 2003-02-20 | |
| Conference Name | 5th Asian Congress for Microcirculation, FEB 20-22, 2003 MANILA, PHILIPPINES |
| Abstract | This study was designed to observe the effect of tumor conditioned medium (TCM) on the proliferation and apoptosis of human umbilical vein endothelial cells (HUVECs). HUVECs were exposed to TCM from breast carcinoma cell line MDA-MB-231, then we measured their proliferation, apoptosis and cell cycle distribution by MTT and flow cytometery (FCM). Following the stimulation of TCM, HUVECs showed higher pro-mitogenic and anti-apoptotic ability than did the negative control group (ECGF-free medium with 20% FBS), but a similar ability to the positive control group (medium with ECGF and 20% FBS). From these results, we can conclude that breast carcinoma cell line MDA-MB-231 could secret soluble pro-angiogenic factors that induce HUVEC angiogenic switching, including cell cycle progression, proliferation and growth. The role and character of these factors remain to be further studied. |
| WOS ID | WOS:000188240800031 |
| Indexed By | CPCI-S |
| Language | 英语 |
| Citation statistics | |
| Document Type | 会议论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/13896 |
| Collection | 力学所知识产出(1956-2008) |
| Corresponding Author | Jin G(靳刚) |
| Recommended Citation GB/T 7714 | Li AL,Li HW,Jin G,et al. The Mitogenic and Anti-Apoptotic Activity of Tumor Conditioned Medium on Endothelium[C]CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2003,29(3-4):375-382,2003. |
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