Knowledge Management System of Institue of Mechanics, CAS
| Nonlinear Mechanical Modeling Of Cell Adhesion | |
Kong D(孔冬) ; Ji BH(季葆华); Dai LH(戴兰宏); Ji, BH (reprint author), Tsing Hua Univ, Dept Engn Mech, Beijing 100084, Peoples R China.
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| Source Publication | Journal of Theoretical Biology
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| 2008 | |
| Pages | 75-84 |
| ISSN | 0022-5193 |
| Abstract | Cell adhesion, which is mediated by the receptor-ligand bonds, plays an essential role in various biological processes. Previous studies often described the force-extension relationship of receptor-ligand bond with linear assumption. However, the force-extension relationship of the bond is intrinsically nonlinear, which should have significant influence on the mechanical behavior of cell adhesion. In this work, a nonlinear mechanical model for cell adhesion is developed, and the adhesive strength was studied at various bond distributions. We find that the nonlinear mechanical behavior of the receptor-ligand bonds is crucial to the adhesive strength and stability. This nonlinear behavior allows more bonds to achieve large bond force simultaneously, and therefore the adhesive strength becomes less sensitive to the change of bond density at the outmost periphery of the adhesive area. In this way, the strength and stability of cell adhesion are soundly enhanced. The nonlinear model describes the cell detachment behavior better than the linear model. (C) 2007 Elsevier Ltd. All rights reserved. |
| Keyword | Cell Adhesion Focal Adhesions Nonlinear Receptor-ligand Bonds Force-extension Relationship Bond Density Membrane-membrane Adhesion Molecular Cross-bridges Detailed Mechanics Focal Contacts Detachment Kinetics Activation Attachment Separation Nanoscale |
| DOI | 10.1016/j.jtbi.2007.09.028 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000252472200007 |
| WOS Keyword | MEMBRANE-MEMBRANE ADHESION ; MOLECULAR CROSS-BRIDGES ; DETAILED MECHANICS ; FOCAL CONTACTS ; DETACHMENT ; KINETICS ; ACTIVATION ; ATTACHMENT ; SEPARATION ; NANOSCALE |
| WOS Research Area | Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology |
| WOS Subject | Biology ; Mathematical & Computational Biology |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/26154 |
| Collection | 力学所知识产出(1956-2008) |
| Corresponding Author | Ji, BH (reprint author), Tsing Hua Univ, Dept Engn Mech, Beijing 100084, Peoples R China. |
| Recommended Citation GB/T 7714 | Kong D,Ji BH,Dai LH,et al. Nonlinear Mechanical Modeling Of Cell Adhesion[J]. Journal of Theoretical Biology,2008:75-84. |
| APA | 孔冬,季葆华,戴兰宏,&Ji, BH .(2008).Nonlinear Mechanical Modeling Of Cell Adhesion.Journal of Theoretical Biology,75-84. |
| MLA | 孔冬,et al."Nonlinear Mechanical Modeling Of Cell Adhesion".Journal of Theoretical Biology (2008):75-84. |
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