Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip

doi:10.1080/10731190903043416

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	Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip
	Wang CL; Li JQ; Li HW; Jin G(靳刚); Wang ZH(王战会); Meng YH(孟永宏); Xiu RJ
发表期刊	Artificial Cells Blood Substitutes and Biotechnology
	2009
卷号	37 期号:4 页码:183-186
ISSN	1073-1199
摘要	The Tie-2 receptor has been shown to play a role in angiogenesis in atherosclerosis. The conventional method assaying the level of soluble Tie-2 (sTie-2) was ELISA. However, this method has some disadvantages. The aims of this research are to establish a more simple detection method, the optical protein-chip based on imaging ellipsomtry (OPC-IE) applying to Tie-2 assay. The sTie-2 biosensor surface on silicon wafer was prepared first, and then serum levels of sTie-2 in 38 patients with AMI were measured on admission (day 1), day 2, day 3 and day 7 after onset of chest pain and 41 healthy controls by ELISA and OPC-IE in parallel. Median level of sTie-2 increased significantly in the AMI patients when compared with the controls. Statistics showed there was a significant correlation in sTie-2 results between the two methods (r=0.923, P0.01). The result of this study showed that the level of sTie-2 increased in AMI, and OPC-IE assay was a fast, reliable, and convenient technique to measure sTie-2 in serum.
关键词	Soluble Tie-2 Acute Myocardial Infarction Elisa Optical Protein-chip Imaging Ellipsometry Imaging Ellipsometry Tyrosine Kinase Tek
DOI	10.1080/10731190903043416
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000267835500007
关键词[WOS]	IMAGING ELLIPSOMETRY ; TYROSINE KINASE ; TEK
WOS研究方向	Biotechnology & Applied Microbiology ; Engineering ; Materials Science
WOS类目	Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Materials Science, Biomaterials
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/26690
专题	微重力重点实验室
通讯作者	Wang CL
推荐引用方式 GB/T 7714	Wang CL,Li JQ,Li HW,et al. Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip[J]. Artificial Cells Blood Substitutes and Biotechnology,2009,37,4,:183-186.
APA	Wang CL.,Li JQ.,Li HW.,Jin G.,Wang ZH.,...&Xiu RJ.(2009).Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip.Artificial Cells Blood Substitutes and Biotechnology,37(4),183-186.
MLA	Wang CL,et al."Soluble Angiopoietin Receptor Tie-2 In Patients With Acute Myocardial Infarction And Its Detection By Optical Protein-Chip".Artificial Cells Blood Substitutes and Biotechnology 37.4(2009):183-186.

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