IMECH-IR  > 力学所知识产出(1956-2008)
β_2整合素-ICAM-1相互作用的动力学测试
展冬颖; 龙勉
Source Publication第八届全国生物力学学术会议论文集.《医用生物力学》,2006,p.98
2006
Pages98
Conference Name第八届全国生物力学学术会议
Conference Date2006
Conference Place香港
Abstract<正>β_2-整合素α_Lβ_2(LFA-1)和α_Mβ_2(MAC-1)是白细胞表面的一类重要粘附分子,与其配体ICAM-1的相互作用在炎症反应和肿瘤转移过程中起着重要作用。在炎症反应发生时,β_2-整合素和ICAM-1的相互作用介导了白细胞与内皮细胞的稳态粘附,是选择素介导滚动粘附的后续反应,使白细胞渗出血管到达炎症部位。在肿瘤转移过程中,白细胞表面的β_2-整合素分别与黑色素瘤细胞及内皮细胞上的ICAM-1作用,使黑色素瘤细胞外渗进入组织,形成继发肿瘤。
Language中文
Document Type会议论文
Identifierhttp://dspace.imech.ac.cn/handle/311007/34258
Collection力学所知识产出(1956-2008)
Corresponding Author展冬颖
Recommended Citation
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展冬颖,龙勉. β_2整合素-ICAM-1相互作用的动力学测试[C]第八届全国生物力学学术会议论文集.《医用生物力学》,2006,p.98,2006:98.
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