| Development of biosensor based on imaging ellipsometry and biomedical applications | |
Jin G(靳刚) ; Meng YH(孟永宏); Liu L(刘丽); Niu Y(牛宇); Chen S(陈涉); Cai Q; Jiang TJ; Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
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| Source Publication | Thin Solid Films
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| 2011 | |
| Volume | 519Issue:9Pages:2750-2757 |
| ISSN | 0040-6090 |
| Abstract | So far, combined with a microfluidic reactor array system, an engineering system of biosensor based on imaging ellipsometry is installed for biomedical applications, such as antibody screen, hepatitis B markers detection, cancer markers spectrum and virus recognition, etc. Furthermore, the biosensor in total internal reflection (TIR) mode has be improved by a spectroscopic light, optimization settings of polarization and low noise CCD which brings an obvious improvement of 10 time increase in the sensitivity and SNR, and 50 times lower concentration in the detection limit with a throughput of 48 independent channels and the time resolution of 0.04 S. (C) 2010 Elsevier B.V. All rights reserved. |
| Keyword | Imaging Ellipsometry Biosensor Protein Microarray Total Internal Reflection Off-null Ellipsometry Optical Protein-chip Optimization Visualization |
| Subject Area | Materials Science ; Physics |
| DOI | 10.1016/j.tsf.2010.12.175 |
| URL | 查看原文 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000289174200040 |
| WOS Keyword | OFF-NULL ELLIPSOMETRY ; OPTICAL PROTEIN-CHIP ; OPTIMIZATION ; VISUALIZATION |
| WOS Research Area | Materials Science ; Physics |
| WOS Subject | Materials Science, Multidisciplinary ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter |
| Department | NML纳米生物光学 |
| Classification | 二类/Q2 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/45099 |
| Collection | 微重力重点实验室 |
| Corresponding Author | Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Jin G,Meng YH,Liu L,et al. Development of biosensor based on imaging ellipsometry and biomedical applications[J]. Thin Solid Films,2011,519,9,:2750-2757. |
| APA | Jin G.,Meng YH.,Liu L.,Niu Y.,Chen S.,...&Jin, G .(2011).Development of biosensor based on imaging ellipsometry and biomedical applications.Thin Solid Films,519(9),2750-2757. |
| MLA | Jin G,et al."Development of biosensor based on imaging ellipsometry and biomedical applications".Thin Solid Films 519.9(2011):2750-2757. |
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| SCI-J2011167.pdf（870KB） | 开放获取 | -- | View Download | |||
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