| Total internal reflection imaging ellipsometry (TIRIE) biosensor sensitivity improvement with low noise imaging device | |
Liu L(刘丽) ; Jin G(靳刚); Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China
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| Source Publication | SENSORS, CAMERAS, AND SYSTEMS FOR INDUSTRIAL, SCIENTIFIC, AND CONSUMER APPLICATIONS XII |
| 2011 | |
| Pages | 78750U |
| Conference Name | Conference on Sensors, Cameras, and Systems for Industrial, Scientific, and Consumer Applications XII |
| Conference Date | JAN 25-27, 2011 |
| Conference Place | San Francisco, CA |
| Abstract | The biosensors with properties of real-time, high throughput and label-free are more and more popular recently, in which the biosensor based on the total internal reflection imaging ellipsometry (TIRIE) is a novel imaging detector for protein interaction processes. In previous work, three techniques are introduced to improve the performance of the biosensor including polarization setting optimization, spectroscopic light source application and low noise CCD detector adoption. In this paper, the effect of the low noise CCD detector technology on the sensitivity and detection limit improvement is analyzed. An obvious improvement of 10 time increase in the sensitivity and SNR, and 50 times lower concentration in the detection limit is obtained by optimization. |
| Keyword | Total Internal Reflection Imaging Ellipsometry Biosensor |
| Department | NML纳米生物光学 |
| ISBN | 978-0-8194-8412-3 |
| URL | 查看原文 |
| Indexed By | CPCI |
| Language | 英语 |
| Document Type | 会议论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/45327 |
| Collection | 微重力重点实验室 |
| Corresponding Author | Jin, G (reprint author), Chinese Acad Sci, NML, Inst Mech, 15 Bei Si Huan W Rd, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Liu L,Jin G,Jin, G . Total internal reflection imaging ellipsometry (TIRIE) biosensor sensitivity improvement with low noise imaging device[C]SENSORS, CAMERAS, AND SYSTEMS FOR INDUSTRIAL, SCIENTIFIC, AND CONSUMER APPLICATIONS XII,2011:78750U. |
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| Conf2011-098.pdf（866KB） | 开放获取 | -- | View Download | |||
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