| 双亲性氧化石墨烯的合成及生物相容性 | |
| Alternative Title | Synthesis and Biocompatibility of Amphiphilic Graphene Oxide |
李宁 ; 张琦; 张庆庆; 宋琴; 齐琳; 王龙; 唐明亮; 靳刚; 程国胜
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| Source Publication | 高等学校化学学报
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| 2013-01-10 | |
| Volume | 34Issue:1Pages:50-54 |
| ISSN | 0251-0790 |
| Abstract | 以六亚甲基二异氰酸酯(HMDI)为偶联剂,通过与氧化石墨烯(GO)中的羧基或羟基反应,形成酰胺键或氨基甲酸酯键活化GO,然后与TWEEN 80中的羟基反应,将双亲性TWEEN分子偶联于GO表面,制备了双亲性GO.所制备的TWEEN 80接枝GO在水、氯仿和己烷等溶剂中均可稳定分散.以PC12及HeLa细胞为细胞模型,考察TWEEN 80接枝GO所制薄膜的细胞毒性,形态学观察及细胞活性检测(Calcein AM & EthD-1荧光染色及MTT检测)结果表明其具有良好的生物相容性. |
| Other Abstract | Amphiphilic functionalization of graphene oxide(GO) is of the essence for its biomedical applications. TWEEN 80-grafted GO was synthesized by a two-step approach. In step 1, GO surface was activated with hexamethylene diisocyanate(HMDI) through a reaction between GO carboxyl or hydroxyl groups and isocyanate. HMDI-activated GO was then grafted by TWEEN 80 in step 2, resulting in amphiphilic GO nanosheets. The fabricated TWEEN 80-grafted GO exhibited excellent dispersibility in various solvents, such as water, chloroform and n-hexane. Furthermore, PC12 and HeLa cells were cultured on TWEEN 80-grafted GO film to assess its cytotoxicity. Cell morphology analysis and cell viability assay(Calcein AM &EthD-1 staining and MTT assay) indicated that the as-synthesized amphiphilic GO had good biocompatibility. |
| Keyword | 双亲性氧化石墨烯 生物相容性 Tween 80 六亚甲基二异氰酸酯 |
| Subject Area | 交叉与边缘领域的力学 |
| URL | 查看原文 |
| Indexed By | EI ; CSCD |
| Language | 中文 |
| WOS ID | WOS:000317085300007 |
| Funding Organization | 国家自然科学基金青年科学基金(批准号:31101059)资助 |
| CSCD ID | CSCD:4742797 |
| Department | NML纳米生物光学 |
| Citation statistics |
Cited Times:8[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/47014 |
| Collection | 微重力重点实验室 |
| Corresponding Author | 程国胜 |
| Recommended Citation GB/T 7714 | 李宁,张琦,张庆庆,等. 双亲性氧化石墨烯的合成及生物相容性[J]. 高等学校化学学报,2013,34,1,:50-54. |
| APA | 李宁.,张琦.,张庆庆.,宋琴.,齐琳.,...&程国胜.(2013).双亲性氧化石墨烯的合成及生物相容性.高等学校化学学报,34(1),50-54. |
| MLA | 李宁,et al."双亲性氧化石墨烯的合成及生物相容性".高等学校化学学报 34.1(2013):50-54. |
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| IMCAS-J2013-029.pdf（953KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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