| A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles | |
Sun JS ; Xianyu YL; Li MM; Liu WW; Zhang L; Liu DB; Liu C(刘超); Hu GQ(胡国庆); Jiang XY; Jiang, XY (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
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| Source Publication | NANOSCALE
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| 2013-06-21 | |
| Volume | 5Issue:12Pages:5262-5265 |
| ISSN | 2040-3364 |
| Abstract | This report demonstrates a microfluidic origami chip to synthesize monodisperse, doxorubicin-loaded poly(lactic-co-glycolic acid) nanoparticles with diameters of ～100 nm, a size optimized for cellular uptake and anticancer efficacy, but difficult to achieve with existing approaches. This three-dimensional design in a microchannel may allow for the fabrication of polymeric nanoparticles in this size regime with ease. |
| Keyword | Microfluidics - Nanoparticles - Synthesis (Chemical) -- Cellular Uptake - Functionalized - Mono-disperse - Poly Lactic-co-glycolic Acid - Polymeric Nanoparticles - Three-dimensional Designs |
| Subject Area | 微机电系统中的流体力学问题 |
| URL | 查看原文 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000319756200011 |
| Funding Organization | MOST [2009CB930001, 2011CB933201, 2012AA030308, 2011CB707604]; NSFC [51105086, 21025520, 51073045, 11272321]; CAS [KJCX2-YW-M15, KJCX2-YW-H18]; [SKLEAC201207] |
| Department | LNM微纳米流体力学 |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/47352 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Jiang, XY (reprint author), Natl Ctr NanoSci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China. |
| Recommended Citation GB/T 7714 | Sun JS,Xianyu YL,Li MM,et al. A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles[J]. NANOSCALE,2013,5,12,:5262-5265. |
| APA | Sun JS.,Xianyu YL.,Li MM.,Liu WW.,Zhang L.,...&Jiang, XY .(2013).A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles.NANOSCALE,5(12),5262-5265. |
| MLA | Sun JS,et al."A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles".NANOSCALE 5.12(2013):5262-5265. |
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