| Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona | |
Hu GQ(胡国庆) ; Jiao B(焦豹); Shi XH(施兴华); Valle RP; Fan QH; Zuo YY; Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China
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| Source Publication | ACS Nano
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| 2013-12 | |
| Volume | 7Issue:12Pages:10525-10533 |
| ISSN | 1936-0851 |
| Abstract | Interaction with the pulmonary surfactant film, being the first line of host defense, represents the initial bio-nano interaction in the lungs. Such interaction determines the fate of the inhaled nanoparticles and their potential therapeutic or toxicological effect. Despite considerable progress in optimizing physicochemical properties of nanoparticles for improved delivery and targeting, the mechanisms by which inhaled nanoparticles interact with the pulmonary surfactant film are still largely unknown. Here, using combined in vitro and in silico methods, we show how hydrophobicity and surface charge of nanoparticles differentially regulate the translocation and interaction with the pulmonary surfactant film. While hydrophilic nanoparticles generally translocate quickly across the pulmonary surfactant film, a significant portion of hydrophobic nanoparticles are trapped by the surfactant film and encapsulated in lipid protrusions upon film compression. Our results support a novel model of pulmonary surfactant lipoprotein corona associated with inhaled nanoparticles of different physicochemical properties. Our data suggest that the study of pulmonary nanotoxicology and nanoparticle-based pulmonary drug delivery should consider this lipoprotein corona. |
| Keyword | Nanoparticle Protein Corona Pulmonary Surfactant Molecular Dynamics |
| Subject Area | 交叉与边缘领域的力学 |
| URL | 查看原文 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000329137100011 |
| Funding Organization | MOST [2011CB707604]; NSFC [11272321, 11272327]; NSF [CBET-1236596] |
| Department | LNM微纳米流体力学 |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/47742 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Hu GQ,Jiao B,Shi XH,et al. Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona[J]. ACS Nano,2013,7,12,:10525-10533. |
| APA | Hu GQ.,Jiao B.,Shi XH.,Valle RP.,Fan QH.,...&Hu, GQ .(2013).Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona.ACS Nano,7(12),10525-10533. |
| MLA | Hu GQ,et al."Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona".ACS Nano 7.12(2013):10525-10533. |
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| 1-nn4054683.pdf（1891KB） | 开放获取 | -- | View Application Full Text | |||
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