| A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles | |
Wang JD ; Chen WW; Sun JS; Liu C(刘超); Yin QF; Zhang L; Xianyu YL; Shi XH(施兴华); Hu GQ(胡国庆); Jiang XY; Sun, JS (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
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| Source Publication | LAB ON A CHIP
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| 2014 | |
| Volume | 14Issue:10Pages:1673-1677 |
| ISSN | 1473-0197 |
| Abstract | This report describes a straightforward but robust tubing method for connecting polydimethylsiloxane (PDMS) microfluidic devices to external equipment. The interconnection is irreversible and can sustain a pressure of up to 4.5 MPa that is characterized experimentally and theoretically. To demonstrate applications of this high-pressure tubing technique, we fabricate a semicircular microfluidic channel to implement a high-throughput, size-controlled synthesis of poly(lactic-co-glycolic acid) (PLGA) nanoparticles ranging from 55 to 135 nm in diameter. This microfluidic device allows for a total flow rate of 410 mL h(-1), resulting in enhanced convective mixing which can be utilized to precipitate small size nanoparticles with a good dispersion. We expect that this tubing technique would be widely used in microfluidic chips for nanoparticle synthesis, cell manipulation, and potentially nanofluidic applications. |
| Subject Area | Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics |
| DOI | 10.1039/c4lc00080c |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000334866500004 |
| Funding Organization | X. J. and J. S. acknowledge financial support from MOST (2011CB933201, 2012AA030308, 2012AA022703 and 2013AA032204), NSFC (51105086, 91213305, 21025520, and 51073045), and the Chinese Academy of Sciences and Beijing Municipal Science & Technology Commission (Z131100002713024). |
| Department | LNM微结构计算力学（筹） |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/48835 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Sun, JS (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China. |
| Recommended Citation GB/T 7714 | Wang JD,Chen WW,Sun JS,et al. A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles[J]. LAB ON A CHIP,2014,14,10,:1673-1677. |
| APA | Wang JD.,Chen WW.,Sun JS.,Liu C.,Yin QF.,...&Sun, JS .(2014).A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles.LAB ON A CHIP,14(10),1673-1677. |
| MLA | Wang JD,et al."A microfluidic tubing method and its application for controlled synthesis of polymeric nanoparticles".LAB ON A CHIP 14.10(2014):1673-1677. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| IMCAS-J2014-122.pdf（1500KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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