| Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake | |
Sun JS(孙佳姝) ; Zhang L(张璐); Wang JL(王九令); Feng Q(冯强); Liu DB; Yin QF(殷其放); Xu DY; Wei YJ(魏宇杰); Ding BQ(丁宝全); Shi XH(施兴华); Jiang XY(蒋兴宇); Shi XH(施兴华)
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| Source Publication | Advanced Materials
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| 2014-12-22 | |
| Volume | 25Issue:8Pages:1402-1407 |
| ISSN | 0935-9648 |
| Abstract | Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations. |
| Keyword | Microfluidics Core–shell Nanoparticles Biomedical Applications Cellular Uptake Drug Delivery |
| Subject Area | 固体力学 ; 生物力学 |
| DOI | 10.1002/adma.201404788 |
| URL | 查看原文 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000350058200015 |
| Department | LNM微结构计算力学（筹） |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/49407 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Shi XH(施兴华) |
| Recommended Citation GB/T 7714 | Sun JS,Zhang L,Wang JL,et al. Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake[J]. Advanced Materials,2014,25,8,:1402-1407. |
| APA | Sun JS.,Zhang L.,Wang JL.,Feng Q.,Liu DB.,...&施兴华.(2014).Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake.Advanced Materials,25(8),1402-1407. |
| MLA | Sun JS,et al."Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake".Advanced Materials 25.8(2014):1402-1407. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| adma201404788.pdf（1876KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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