| Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels | |
Liu C(刘超) ; Xue CD; Chen XD(陈晓东); Shan L; Tian Y; Hu GQ(胡国庆); Hu GQ(胡国庆), State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics,Chinese Academy of Sciences, Beijing 100190, China
| |
| Source Publication | Analytical Chemistry
 |
| 2015-05-19 | |
| Volume | 87Issue:12Pages:6041-6048 |
| ISSN | 0003-2700 |
| Abstract | Viscoelasticity-induced particle migration has recently received increasing attention due to its ability to obtain high-quality focusing over a wide range of flow rates. However, its application is limited to low throughput regime since the particles can defocus as flow rate increases. Using an engineered carrier medium with constant and low viscosity and strong elasticity, the sample flow rates are improved to be 1 order of magnitude higher than those in existing studies. Utilizing differential focusing of particles of different sizes, here, we present sheathless particle/cell separation in simple straight microchannels that possess excellent parallelizability for further throughput enhancement. The present method can be implemented over a wide range of particle/cell sizes and flow rates. We successfully separate small particles from larger particles, MCF-7 cells from red blood cells (RBCs), and Escherichia coli (E. coli) bacteria from RBCs in different straight microchannels. The proposed method could broaden the applications of viscoelastic microfluidic devices to particle/cell separation due to the enhanced sample throughput and simple channel design. |
| DOI | 10.1021/acs.analchem.5b00516 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000356755100027 |
| WOS Keyword | VISCOSITY ELASTIC FLUIDS ; MICROFLUIDIC CHANNEL ; FLOW FRACTIONATION ; BLOOD ; CHIP ; MIGRATION ; TECHNOLOGY ; FILTRATION ; CYLINDER ; FOCUSER |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Analytical |
| Department | LNM微纳米流体力学 |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/52049 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Hu GQ(胡国庆), State Key Laboratory of Nonlinear Mechanics, Institute of Mechanics,Chinese Academy of Sciences, Beijing 100190, China |
| Recommended Citation GB/T 7714 | Liu C,Xue CD,Chen XD,et al. Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels[J]. Analytical Chemistry,2015,87,12,:6041-6048. |
| APA | Liu C.,Xue CD.,Chen XD.,Shan L.,Tian Y.,...&Hu GQ.(2015).Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels.Analytical Chemistry,87(12),6041-6048. |
| MLA | Liu C,et al."Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels".Analytical Chemistry 87.12(2015):6041-6048. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| J2015-002.pdf（1235KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment