| Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters | |
Feng Q; Zhang L; Liu C; Li XY; Hu GQ(胡国庆) ; Sun JS; Jiang XY; Feng, Q (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China.
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| Source Publication | Biomicrofluidics
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| 2015-09 | |
| Volume | 9Issue:5Pages:52604 |
| ISSN | 1932-1058 |
| Abstract | Core-shell hybrid nanoparticles (NPs) for drug delivery have attracted numerous attentions due to their enhanced therapeutic efficacy and good biocompatibility. In this work, we fabricate a two-stage microfluidic chip to implement a high-throughput, one-step, and size-tunable synthesis of mono-disperse lipid-poly (lactic-co-glycolic acid) NPs. The size of hybrid NPs is tunable by varying the flow rates inside the two-stage microfluidic chip. To elucidate the mechanism of size-controllable generation of hybrid NPs, we observe the flow field in the microchannel with confocal microscope and perform the simulation by a numerical model. Both the experimental and numerical results indicate an enhanced mixing effect at high flow rate, thus resulting in the assembly of small and monodisperse hybrid NPs. In vitro experiments show that the large hybrid NPs are more likely to be aggregated in serum and exhibit a lower cellular uptake efficacy than the small ones. This microfluidic chip shows great promise as a robust platform for optimization of nano drug delivery system. (C) 2015 AIP Publishing LLC. |
| DOI | 10.1063/1.4922957 |
| URL | 查看原文 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000364407300005 |
| WOS Keyword | CORE-SHELL NANOPARTICLES ; CELLULAR UPTAKE ; PLGA NANOPARTICLES ; DRUG-DELIVERY ; PARTICLE-SIZE ; LIPOSOMES ; RELEASE ; DEVICES ; CAPSULES ; PLATFORM |
| WOS Research Area | Biochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other Topics ; Physics |
| WOS Subject | Biochemical Research Methods ; Biophysics ; Nanoscience & Nanotechnology ; Physics, Fluids & Plasmas |
| Funding Organization | This work was supported financially by MOST (2013AA032204 and 2013YQ190467), NSFC (21475028, 11422215, and 11272327), and Chinese Academy of Sciences (XDA09030305 and XDA09030308). |
| Department | LNM微纳米流体力学 |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/52051 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Feng, Q (reprint author), Natl Ctr NanoSci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China. |
| Recommended Citation GB/T 7714 | Feng Q,Zhang L,Liu C,et al. Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters[J]. Biomicrofluidics,2015,9,5,:52604. |
| APA | Feng Q.,Zhang L.,Liu C.,Li XY.,胡国庆.,...&Feng, Q .(2015).Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters.Biomicrofluidics,9(5),52604. |
| MLA | Feng Q,et al."Microfluidic based high throughput synthesis of lipid-polymer hybrid nanoparticles with tunable diameters".Biomicrofluidics 9.5(2015):52604. |
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| 1.4922957.pdf（2516KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-ND | View Download | |
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