| Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies | |
| Wang HJ; Liu JH; Zheng X(郑旭); Rong XH; Zheng XW; Peng HY; Li ZH(李战华); Li MJ; Liu, LY; Silber-Li, ZH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China. | |
| Source Publication | SCIENTIFIC REPORTS
 |
| 2015-06-04 | |
| Volume | 5Pages:10945 |
| ISSN | 2045-2322 |
| Abstract | Percutaneous coronary intervention (PCI), especially coronary stent implantation, has been shown to be an effective treatment for coronary artery disease. However, in-stent restenosis is one of the longstanding unsolvable problems following PCI. Although stents implanted inside narrowed vessels recover normal flux of blood flows, they instantaneously change the wall shear stress (WSS) distribution on the vessel surface. Improper stent implantation positions bring high possibilities of restenosis as it enlarges the low WSS regions and subsequently stimulates more epithelial cell outgrowth on vessel walls. To optimize the stent position for lowering the risk of restenosis, we successfully established a digital three-dimensional (3-D) model based on a real clinical coronary artery and analysed the optimal stenting strategies by computational simulation. Via microfabrication and 3-D printing technology, the digital model was also converted into in vitro microfluidic models with 3-D micro channels. Simultaneously, physicians placed real stents inside them; i.e., they performed "virtual surgeries". The hydrodynamic experimental results showed that the microfluidic models highly inosculated the simulations. Therefore, our study not only demonstrated that the half-cross stenting strategy could maximally reduce restenosis risks but also indicated that 3-D printing combined with clinical image reconstruction is a promising method for future angiocardiopathy research. |
| DOI | 10.1038/srep10945 |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000355724100001 |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| Funding Organization | State Key Development Program for Basic Research of China [2013CB837200] ; National Natural Science Foundation of China [11474345, 11272322, 11202219] ; Beijing Natural Science Foundation [7154221] |
| Department | LNM微纳米流体力学 |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/54961 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Silber-Li, ZH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China. |
| Recommended Citation GB/T 7714 | Wang HJ,Liu JH,Zheng X,et al. Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies[J]. SCIENTIFIC REPORTS,2015,5:10945. |
| APA | Wang HJ.,Liu JH.,郑旭.,Rong XH.,Zheng XW.,...&Silber-Li, ZH .(2015).Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies.SCIENTIFIC REPORTS,5,10945. |
| MLA | Wang HJ,et al."Three-dimensional virtual surgery models for percutaneous coronary intervention (PCI) optimization strategies".SCIENTIFIC REPORTS 5(2015):10945. |
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| IMCAS-J2015-110.pdf（1764KB） | 开放获取 | CC BY-ND | View Download | |||
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