| Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension |
| He XC; Lin M ; Sha BY; Feng SS; Shi XH(施兴华); Qu ZG; Xu F; Qu, ZG (reprint author), Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China.
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| Source Publication | SCIENTIFIC REPORTS
(IF:4.011[JCR-2018],4.525[5-Year]) |
| 2015-08-03
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| Volume | 5Pages:12808 |
| ISSN | 2045-2322
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| Abstract | Understanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane tension on translocation, it is generally thought that tension should disorder the membrane structure and weaken its strength, thereby facilitating penetration. However, our coarse-grained molecular dynamics simulation results showed that membrane tension can restrain polyarginine translocation across the asymmetric membrane and that this effect increases with increasing membrane tension. We also analyzed the structural properties and lipid topology of the tensed membrane to explain the phenomena. Simulation results provide important molecular information on the potential translocation mechanism of peptides across the asymmetric membrane under tension as well as new insights in drug and gene delivery. |
| Subject Area | Science & Technology - Other Topics
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| DOI | 10.1038/srep12808
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| URL | 查看原文
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| Indexed By | SCI
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| Language | 英语
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| WOS ID | WOS:000358853400001
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| WOS Research Area | Science & Technology - Other Topics
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| WOS Subject | Multidisciplinary Sciences
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| Funding Organization | National Natural Science Foundation of China [51322604, 51176149, 11372243, 81301040, 11272327, 11422215]
; Major International Joint Research Program of China [11120101002]
; International Science & Technology Cooperation Program of China [2013DFG02930]
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| Department | LNM微结构计算力学（筹）
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| Classification | 一类
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| Citation statistics |
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| Document Type | 期刊论文
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| Identifier | http://dspace.imech.ac.cn/handle/311007/55326
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| Collection | 非线性力学国家重点实验室
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| Corresponding Author | Qu, ZG (reprint author), Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China. |
Recommended Citation
GB/T 7714 |
He XC,Lin M,Sha BY,et al. Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension[J]. SCIENTIFIC REPORTS,2015,5:12808.
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| APA |
He XC.,Lin M.,Sha BY.,Feng SS.,Shi XH.,...&Qu, ZG .(2015).Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension.SCIENTIFIC REPORTS,5,12808.
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| MLA |
He XC,et al."Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension".SCIENTIFIC REPORTS 5(2015):12808.
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