Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning

doi:10.1021/acs.analchem.6b04564

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	Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning
	Liu C; Ding BQ; Xue CD; Tian Y; Hu GQ(胡国庆); Su JS; Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.; Hu, GQ (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.; Su, JS (reprint author), Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
发表期刊	ANALYTICAL CHEMISTRY
	2016
卷号	88 期号:24 页码:12547-12553
ISSN	0003-2700
摘要	Viscoelastic microfluidics becomes an efficient and label free hydrodynamic technology to enrich and separate micrometer-scale particles, including blood cells, circulating tumor cells, and bacteria. However, the manipulation of nanoscale particles by viscoelastic microfluidics remains a major challenge, because the viscoelastic force acting on the smaller particle decreases dramatically. In contrast to the commonly used polymer solutions of high molecular weight, herein we utilize the aqueous solutions of poly(ethylene oxide) (PEO) of low molecular weight with minimized shear thinning but sufficient elastic force for high-quality focusing and separation of various nanoparticles. The focusing efficiencies of 100 nm polystyrene (PS) nanoparticles and 2-DNA molecules are 84% and 85%, respectively, in a double spiral microchannel, without the aid of sheath flows. Furthermore, we demonstrate the size-based viscoelastic separation of two sets of binary mixtures-100/2000 nm PS particles and 2-DNA molecules/blood platelets all achieving separation efficiencies of >95% in the same device. Our proposal technique would be a promising approach for enrichment/separation of the nanoparticles encountered in applications of analytical chemistry and nanotechnology.
DOI	10.1021/acs.analchem.6b04564
URL	查看原文
收录类别	SCI
语种	英语
WOS记录号	WOS:000390621000078
WOS研究方向	Chemistry
WOS类目	Chemistry, Analytical
项目资助者	NSFC [11572334, 91543125, 11272321, 21475028, 21622503] ; CAS [QYZDB-SSW-JSC036, XDB22040403] ; MOST [2013AA032204] ; Youth Innovation Promotion Association CAS
课题组名称	LNM微纳米流体力学
论文分区	一类
引用统计	被引频次：79[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/59974
专题	非线性力学国家重点实验室
通讯作者	Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.; Hu, GQ (reprint author), Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China.; Su, JS (reprint author), Natl Ctr NanoSci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.
推荐引用方式 GB/T 7714	Liu C,Ding BQ,Xue CD,et al. Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning[J]. ANALYTICAL CHEMISTRY,2016,88,24,:12547-12553.
APA	Liu C.,Ding BQ.,Xue CD.,Tian Y.,胡国庆.,...&Su, JS .(2016).Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning.ANALYTICAL CHEMISTRY,88(24),12547-12553.
MLA	Liu C,et al."Sheathless Focusing and Separation of Diverse Nanoparticles in Viscoelastic Solutions with Minimized Shear Thinning".ANALYTICAL CHEMISTRY 88.24(2016):12547-12553.

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