Knowledge Management System of Institue of Mechanics, CAS
| Silicon surface modification with supported phospholipids bilayer for biosensor based on imaging ellipsometry | |
Chen YY(陈艳艳) ; Wang ZH; Liu Y; Liang W; Chang WR; Jin G(靳刚)
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| Source Publication | IFMBE Proceedings |
| 2008 | |
| Conference Name | 4th European Conference of the International Federation for Medical and Biological Engineering, ECIFMBE 2008 |
| Conference Date | November 23, 2008 - November 27, 2008 |
| Conference Place | Antwerp, Belgium |
| Abstract | A method is presented for fabricating supported phospholipids bilayer on silicon surface for biosensor based on imaging ellipsometry. The lipid bilayer prepared by covalent immobilization of phosphatidylethanolamine layer on silicon surface followed by adsorption of PEG functionalized phospholipids layer, is highly protein resistant and stable, which can withstand multiple cycles of drying and rehydration, remaining intact in various buffers. Proteins covalently immobilized on the bilayer by the terminal p-nitrophenylcarbonyl or carboxyl group of PEG remain higher bioactivity than that immobilized on silicon surface directly. © 2009 Springer Berlin Heidelberg. |
| Keyword | Bi-layer Carboxyl Groups Covalent Immobilization Functionalized Imaging Ellipsometry Microfluidic Array Phosphatidylethanolamine Phospholipids Bilayer Silicon Surfaces |
| WOS ID | WOS:000299998500551 |
| URL | 查看原文 |
| Indexed By | CPCI-S ; EI |
| Language | 英语 |
| Citation statistics | |
| Document Type | 会议论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/60310 |
| Collection | 力学所知识产出(1956-2008) |
| Recommended Citation GB/T 7714 | Chen YY,Wang ZH,Liu Y,et al. Silicon surface modification with supported phospholipids bilayer for biosensor based on imaging ellipsometry[C]IFMBE Proceedings,2008. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| CaEi077.pdf（205KB） | 会议论文 | 开放获取 | CC BY-NC-SA | View Download | ||
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