| Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow | |
Du Y(杜宇) ; Peng S(彭爽); Cui Yuhong; Lv SQ(吕守芹); Zhang Y(章燕); Long M(龙勉)
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| Source Publication | Theoretical and Applied Mechanics Letters
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| 2015 | |
| Volume | 5Issue:6Pages:216-221 |
| ISSN | 2095-0349 |
| Abstract | Blood cell aggregation and adhesion to endothelial cells under shear flow are crucial to many biological processes such as thrombi formation, inflammatory cascade, and tumor metastasis, in which these cellular interactions are mainly mediated by the underlying receptor-ligand bindings. While theoretical modeling of aggregation dynamics and adhesion kinetics of interacting cells have been well studied separately, how to couple these two processes remains unclear. Here we develop a combined model that couples cellular aggregation dynamics and adhesion kinetics under shear flow. The impacts of shear rate (or shear stress) and molecular binding affinity were elucidated. This study provides a unified model where the action of a fluid flow drives cell aggregation and adhesion under the modulations of the mechanical shear flow and receptor-ligand interaction kinetics. It offers an insight into understanding the relevant biological processes and functions. |
| Keyword | Cell Adhesion Aggregation Kinetics Shear Flow |
| Indexed By | CSCD |
| Language | 英语 |
| Funding Organization | supported by National Natural Science Foundation of China ; National Key Basic Research Foundation of China ; Strategic Priority Research Program |
| CSCD ID | CSCD:5590448 |
| Department | NML分子-细胞生物力学与空间生命科学 |
| Ranking | true |
| Citation statistics |
Cited Times:1[CSCD]
[CSCD Record]
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| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/60781 |
| Collection | 微重力重点实验室 |
| Recommended Citation GB/T 7714 | Du Y,Peng S,Cui Yuhong,et al. Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow[J]. Theoretical and Applied Mechanics Letters,2015,5,6,:216-221. |
| APA | 杜宇,彭爽,Cui Yuhong,吕守芹,章燕,&龙勉.(2015).Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow.Theoretical and Applied Mechanics Letters,5(6),216-221. |
| MLA | 杜宇,et al."Combined modeling of cell aggregation and adhesion mediated by receptor-ligand interactions under shear flow".Theoretical and Applied Mechanics Letters 5.6(2015):216-221. |
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| File Name/Size | DocType | Version | Access | License | ||
| taml005.pdf（961KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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