| Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model | |
Tang H; Jia WS; Hou XL ; Zhao YN; Huan Y(郇勇); Chen W; Yu W; Zhu MMO; Ye G; Chen B; Dai JW
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| Source Publication | BIOMEDICAL MATERIALS
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| 2018-05-01 | |
| Volume | 13Issue:3Pages:31001 |
| ISSN | 1748-6041 |
| Abstract | Regeneration of the corpus spongiosum helps prevent complications following urethral reconstruction, but currently there is a lack of effective therapeutic methods in clinic. In previous studies, we fabricated a fusion protein collagen-binding domain (CBD)-basic fibroblast growth factor (bFGF) that specifically binds to and releases from collagen biomaterials. We demonstrated that CBD-bFGF could promote angiogenesis and tissue regeneration in vivo. In this study, we established a beagle model with extensive urethral defects, and reconstructed the defects with collagen biomaterials that were unmodified or modified with CBD-bFGF. The results demonstrate that CBD-bFGF promotes corpus spongiosum regeneration resulting in improved outcomes following urethral reconstruction. Modifying collagen biomaterials with CBD-bFGF may represent an effective strategy for urethral substitution in urethral reconstruction. |
| Keyword | collagen basic fibroblast growth factor collagen-binding domain corpus spongiosum urethral regeneration |
| DOI | 10.1088/1748-605X/aa9f01 |
| URL | 查看原文 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000425739900001 |
| WOS Keyword | FIBROBLAST-GROWTH-FACTOR ; URETHRAL RECONSTRUCTION ; STEM-CELLS ; RABBIT MODEL ; BINDING BFGF ; DEFECTS ; INJURY ; RATS ; URETHROPLASTY ; IMPROVES |
| WOS Research Area | Engineering, Biomedical ; Materials Science, Biomaterials |
| WOS Subject | Engineering ; Materials Science |
| Funding Organization | National Key R&D Program of China [2016YFC1000807, 2016YFC1000800, 2016YFC1000801, 2016YFC1000802] |
| Classification | 二类 |
| Ranking | 5 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/77924 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Third Mil Med Univ, Army Med Univ, Coll Prevent Med, Dept Chem Def Med, Chongqing 400038, Peoples R China 2.Third Mil Med Univ, Army Med Univ, Xinqiao Hosp, Dept Urol,Ctr Nephrol, Chongqing 400037, Peoples R China 3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China 5.Third Mil Med Univ, Army Med Univ, Coll Prevent Med, Cadet 17 Battal, Chongqing 400038, Peoples R China 6.Third Mil Med Univ, Army Med Univ, Coll Prevent Med,Chongqing Engn Res Ctr Nanomed, Inst Combined Injury,State Key Lab Trauma Burns &, Chongqing 400038, Peoples R China |
| Recommended Citation GB/T 7714 | Tang H,Jia WS,Hou XL,et al. Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model[J]. BIOMEDICAL MATERIALS,2018,13,3,:31001. |
| APA | Tang H.,Jia WS.,Hou XL.,Zhao YN.,Huan Y.,...&Dai JW.(2018).Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model.BIOMEDICAL MATERIALS,13(3),31001. |
| MLA | Tang H,et al."Collagen scaffolds tethered with bFGF promote corpus spongiosum regeneration in a beagle model".BIOMEDICAL MATERIALS 13.3(2018):31001. |
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| IrJ2018312.pdf（4074KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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