| Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein | |
| Dong WJ1,2,3; Ye J1,2,3; Zhou JZ1,2,3; Wang WJ1,2,3; Wang HL1,2,3; Zheng X(郑旭)4; Yang YF1,2,3; Xia XJ1,2,3; Liu YL1,2,3 | |
| Corresponding Author | Liu, Yuling([email protected]) |
| Source Publication | ACTA PHARMACEUTICA SINICA B
 |
| 2020-08-01 | |
| Volume | 10Issue:8Pages:1576-1585 |
| ISSN | 2211-3835 |
| Abstract | Efficient mucosal delivery remains a major challenge for the reason of the respiratory tract mucus act as a formidable barrier to nanocarriers by trapping and clearing foreign particulates. The surface property of nanoparticles determines their retention and penetration ability within the respiratory tract mucus. However, the interaction between nanoparticles and mucus, and how these interactions impact distribution has not been extensively investigated. In this study, polymeric nanoparticles loaded with a baicalein-phospholipid complex were modified with two kinds of polymers, mucoadhesive and mucus-penetrative polymer. Systematic investigations on the physicochemical property, mucus penetration, transepithelial transport, and tissue distribution were performed to evaluate the interaction of nanoparticles with the respiratory tract. Both nanoparticles had a similar particle size and good biocompatibility, exhibited a sustained-release profile, but showed a considerable difference in zeta potential. Interestingly, mucus-penetrative nanoparticles exhibited a higher diffusion rate in mucus, deeper penetration across the mucus layer, enhanced in vitro cellular uptake, increased drug distribution in airways, and superior local distribution and bioavailability as compared to mucoadhesive nanoparticles. These results indicate the potential of mucus-penetrative nanoparticles in design of a rational delivery system to improve the efficiency of inhaled therapy by promoting mucus penetration and increasing local distribution and bioavailability. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. |
| Keyword | Nanoparticles Inhaled delivery Mucus-penetrative Mucoadhesive Baicalein |
| DOI | 10.1016/j.apsb.2019.10.002 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000567649600016 |
| WOS Keyword | BIODEGRADABLE NANOPARTICLES ; PULMONARY DELIVERY ; PACLITAXEL ; BIOAVAILABILITY ; ABSORPTION ; INHALATION ; THERAPY |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Pharmacology & Pharmacy |
| Funding Project | National Science and Technology Major Project of China[2018ZX09721003] ; National Science and Technology Major Project of China[2018ZX09711001] |
| Funding Organization | National Science and Technology Major Project of China |
| Classification | 一类 |
| Ranking | 5+ |
| Contributor | Liu, Yuling |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/85214 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China; 2.Peking Union Med Coll, Beijing 100050, Peoples R China; 3.Chinese Acad Med Sci, Inst Mat Med, Beijing Key Lab Drug Delivery Technol & Novel For, Beijing 100050, Peoples R China; 4.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Dong WJ,Ye J,Zhou JZ,et al. Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein[J]. ACTA PHARMACEUTICA SINICA B,2020,10,8,:1576-1585.Rp_Au:Liu, Yuling |
| APA | Dong WJ.,Ye J.,Zhou JZ.,Wang WJ.,Wang HL.,...&Liu YL.(2020).Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein.ACTA PHARMACEUTICA SINICA B,10(8),1576-1585. |
| MLA | Dong WJ,et al."Comparative study of mucoadhesive and mucus-penetrative nanoparticles based on phospholipid complex to overcome the mucus barrier for inhaled delivery of baicalein".ACTA PHARMACEUTICA SINICA B 10.8(2020):1576-1585. |
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| Jp2020357.pdf（1986KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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