| Amphiphilic silver nanoclusters show active nano-bio interaction with compelling antibacterial activity against multidrug-resistant bacteria | |
Chen YJ1,2; Ren LT1,3,4; Sun LX5,6; Bai X(白轩)2,7 ; Zhuang Q1,2; Cao B5,6; Hu GQ8; Zheng NF3,4; Liu SJ1,2
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| Corresponding Author | Zheng, Nanfeng([email protected]) ; Liu, Sijin([email protected]) |
| Source Publication | NPG ASIA MATERIALS
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| 2020-09-04 | |
| Volume | 12Issue:1Pages:15 |
| ISSN | 1884-4049 |
| Abstract | Multidrug resistance represents a growing threat to human beings, and alternative antimicrobial regimens to conventional antibiotic paradigms are being extensively searched to fight against multidrug-resistant bacteria (MDRB). Although the antimicrobial potency of silver nanomaterials (AgNMs) has been previously elaborated, their efficacy against MDRB still remains to be strengthened. Here, our data revealed that small-sized silver nanoclusters (AgNCs) are superior to conventional silver nanoparticles (AgNPs) as robust antimicrobials against multidrug-resistant (MDR) Pseudomonas aeruginosa (P. aeruginosa). The core structure and surface ligands of AgNCs are crucial for the outstanding antibacterial activity of AgNCs. On the one hand, due to the presence of amphiphilic ligands, AgNCs are relatively prone to associate with the cell membrane and partake in endocytosis with targeted bacterial cells. Molecular dynamics simulations also corroborated this finding. On the other hand, the nanocluster structure of AgNCs led to strong peroxidase-like activity associated with massive production of reactive oxygen species (ROS), which contributes to their overall bactericidal potency. These outstanding features of AgNCs result in elevated bacterial killing efficacy by impairing the cell wall/membrane, promoting oxidative stress and attenuating pivotal cellular processes, e.g., ATP synthesis. Notably, AgNCs manifested great efficacy in treating P. aeruginosa-generated pneumonia in mice and increased the survival of infected animals, as well as exhibited excellent biocompatibility. Taken together, the results of this study pinpoint the great promise of AgNCs as new alternative therapeutics against MDR P. aeruginosa. Biomaterials: A silver bullet against drug-resistant bacteriaA silver nanomaterial that can destroy drug-resistant bacteria has been developed by researchers in China. The rise of antibiotic-resistant bacteria is a major source of concern in global health. Silver has long been known to have antibacterial properties, and so scientists are returning to it as a possible agent to combat these multidrug-resistant bacteria. While silver nanoparticles have previously been shown to have good antibacterial activity, a team led by Nanfeng Zheng, Xiamen University, and Sijin Liu, Chinese Academy of Sciences, Beijing, have shown that small clusters of silver particles are even better. The researchers determined the optimal size, structure and surface properties of antibacterial nanosilver clusters. They used their nanoclusters to treat pneumonia in mice caused by the multidrug-resistant bacteria Pseudomonas aeruginosa, increasing their survival rates. Our findings unearth the great importance of the size, core structure, and surface ligands in dictating the antibacterial activity of silver nanoclusters (AgNCs). Owing to the presence of amphiphilic ligands, AgNCs are more prone to adsorb the membrane and following endocytosis towards targeted bacterial cells, associated with membrane damage, as reflected by reinforced release of malondialdehyde (MDA). AgNCs bear strong peroxidase-like activity, coupled to massive production of reactive oxygen species (ROS). Altogether, these outstanding features of AgNCs resultantly elevated the bacteria-killing efficacy through impairing cell wall/membrane, promoting oxidative stress and attenuating pivotal cellular processes, e.g., ATP synthesis. org/1999/xlink" xlink:href="41427_2020_239_Figa_HTML.png"> |
| DOI | 10.1038/s41427-020-00239-y |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000570040200001 |
| WOS Keyword | COARSE-GRAINED MODEL ; PSEUDOMONAS-AERUGINOSA ; ANTIMICROBIAL ACTIVITY ; GOLD NANOPARTICLES ; LABEL-FREE ; OXIDE ; MECHANISMS ; MEMBRANE |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Multidisciplinary |
| Funding Project | National Natural Science Foundation of China[21637004] ; National Natural Science Foundation of China[21920102007] ; National Natural Science Foundation of China[21922611] ; National Natural Science Foundation of China[21707161] ; Beijing Natural Science Foundation[8191002] ; Chinese Academy of Sciences[121311KYSB20190010] |
| Funding Organization | National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Chinese Academy of Sciences |
| Classification | 一类 |
| Ranking | 4 |
| Contributor | Zheng, Nanfeng ; Liu, Sijin |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/85232 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Xiamen Univ, Coll Chem & Chem Engn, Collaborat Innovat Ctr Chem Energy Mat, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China; 4.Xiamen Univ, Coll Chem & Chem Engn, Natl & Local Joint Engn Res Ctr Preparat Technol, Xiamen 361005, Peoples R China; 5.China Japan Friendship Hosp, Dept Pulm & Crit Care Med, Ctr Resp Med, Beijing 100029, Peoples R China; 6.Natl Clin Res Ctr Resp Dis, Beijing 100029, Peoples R China; 7.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; 8.Zhejiang Univ, Dept Engn Mech, Hangzhou 310027, Peoples R China |
| Recommended Citation GB/T 7714 | Chen YJ,Ren LT,Sun LX,et al. Amphiphilic silver nanoclusters show active nano-bio interaction with compelling antibacterial activity against multidrug-resistant bacteria[J]. NPG ASIA MATERIALS,2020,12,1,:15.Rp_Au:Zheng, Nanfeng, Liu, Sijin |
| APA | Chen YJ.,Ren LT.,Sun LX.,白轩.,Zhuang Q.,...&Liu SJ.(2020).Amphiphilic silver nanoclusters show active nano-bio interaction with compelling antibacterial activity against multidrug-resistant bacteria.NPG ASIA MATERIALS,12(1),15. |
| MLA | Chen YJ,et al."Amphiphilic silver nanoclusters show active nano-bio interaction with compelling antibacterial activity against multidrug-resistant bacteria".NPG ASIA MATERIALS 12.1(2020):15. |
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| Jp2020351.pdf（3938KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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