| Interplay Between Receptor-Ligand Binding and Lipid Domain Formation Depends on the Mobility of Ligands in Cell-Substrate Adhesion | |
Li L(李龙)1,2 ; Wang XH(王小环)1,2,3; Wu, Helong4; Shao YF(邵颖峰)1,2; Wu, Huaping4; Song F(宋凡)1,2,3
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| Corresponding Author | Shao, Yingfeng([email protected]) ; Wu, Huaping([email protected]) ; Song, Fan([email protected]) |
| Source Publication | FRONTIERS IN MOLECULAR BIOSCIENCES
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| 2021-04-12 | |
| Volume | 8Pages:9 |
| Abstract | Cell-cell adhesion and the adhesion of cells to extracellular matrix are mediated by the specific binding of receptors on the cell membrane to their cognate ligands on the opposing surface. The adhesion receptors can exhibit affinity for nanoscale lipid clusters that form in the cell membrane. Experimental studies of such adhesion systems often involve a cell adhering either to a solid surface with immobile ligands or a supported lipid bilayer with mobile ligands. A central question in these cell-substrate adhesions is how the mobility of the ligands physically affects their binding to the adhesion receptors and thereby the behavior of the nanoscale lipid clusters associated with the receptors. Using a statistical mechanical model and Monte Carlo simulations for the adhesion of cells to substrates with ligands, we find that, for mobile ligands, binding to adhesion receptors can promote the formation of mesoscale lipid domains, which in turn enhances the receptor-ligand binding. However, in the case of immobile ligands, the receptor-ligand binding and the tendency for the nanoscale lipid clusters to further coalesce depend on the distribution of the ligands on the substrate. Our findings help to explain why different adhesion experiments for identifying the interplay between receptor-ligand binding and heterogeneities in cell membranes led to contradictory results. |
| Keyword | cell adhesion receptor-ligand binding nanoscale lipid cluster ligand mobility phase separation binding constant |
| DOI | 10.3389/fmolb.2021.655662 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000643696100001 |
| WOS Research Area | Biochemistry & Molecular Biology |
| WOS Subject | Biochemistry & Molecular Biology |
| Funding Project | NSFC Basic Science Center Program for Multiscale Problems in Nonlinear Mechanics[11988102] ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102] |
| Funding Organization | NSFC Basic Science Center Program for Multiscale Problems in Nonlinear Mechanics ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| Classification | 二类 |
| Ranking | 1 |
| Contributor | Shao, Yingfeng ; Wu, Huaping ; Song, Fan |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/86501 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, State Key Lab Nonlinear Mech LNM, Inst Mech, Beijing, Peoples R China; 2.Chinese Acad Sci, Beijing Key Lab Engn Construct & Mechanobiol, Inst Mech, Beijing, Peoples R China; 3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China; 4.Zhejiang Univ Technol, Coll Mech Engn, Hangzhou, Peoples R China |
| Recommended Citation GB/T 7714 | Li L,Wang XH,Wu, Helong,et al. Interplay Between Receptor-Ligand Binding and Lipid Domain Formation Depends on the Mobility of Ligands in Cell-Substrate Adhesion[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2021,8:9.Rp_Au:Shao, Yingfeng, Wu, Huaping, Song, Fan |
| APA | 李龙,王小环,Wu, Helong,邵颖峰,Wu, Huaping,&宋凡.(2021).Interplay Between Receptor-Ligand Binding and Lipid Domain Formation Depends on the Mobility of Ligands in Cell-Substrate Adhesion.FRONTIERS IN MOLECULAR BIOSCIENCES,8,9. |
| MLA | 李龙,et al."Interplay Between Receptor-Ligand Binding and Lipid Domain Formation Depends on the Mobility of Ligands in Cell-Substrate Adhesion".FRONTIERS IN MOLECULAR BIOSCIENCES 8(2021):9. |
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| File Name/Size | DocType | Version | Access | License | ||
| Jp2021189.pdf（1678KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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