| Influence of lipid rafts on pattern formation during T-cell adhesion | |
Li L(李龙)1,2; Hu, Jinglei3,4,8; Rozycki, Bartosz5; Wang XH(王小环)1,2,6; Wu, Helong7; Song F(宋凡)1,2,6
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| Corresponding Author | Hu, Jinglei([email protected]) ; Rozycki, Bartosz([email protected]) |
| Source Publication | NEW JOURNAL OF PHYSICS
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| 2021-04-01 | |
| Volume | 23Issue:4Pages:14 |
| ISSN | 1367-2630 |
| Abstract | Adhesion of T cells to antigen presenting cells is mediated by the TCR-MHCp and LFA1-ICAM1 protein complexes. These intercellular protein complexes segregate and form characteristic special patterns in the cell contact zone. Previous studies have attempted to explain the mechanisms of formation of these patterns. While emphasis has been put on membrane elasticity and active cytoskeletal transport, it remains unclear whether and how the pattern formation process is related to lipid rafts, which are nanoscale molecular clusters enriched in cholesterol and saturated phospholipids in cell membranes. Using Monte Carlo simulations of a statistical mechanical model for T-cell adhesion, we find that lipid rafts can lead to the formation of intermediate pattern with a ring of LFA1-ICAM1 complexes around a central domain of TCR-MHCp complexes even in the absence of active transport of T-cell receptor (TCR) molecules toward the center of the contact zone. In the presence of active TCR transport, lipid rafts can accelerate the formation of this monocentric pattern. We also find that lipid rafts have a strong stabilizing effect on the monocentric pattern after removal of the active TCR transport. Our results not only help to explain recent experimental observations, but also demonstrate that lipid rafts can cooperate with active cytoskeletal transport during the immunological synapse formation. |
| Keyword | T-cell adhesion immunological synapse pattern formation lipid raft intercellular protein binding |
| DOI | 10.1088/1367-2630/abeacb |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000646924900001 |
| WOS Research Area | Physics |
| WOS Subject | Physics, Multidisciplinary |
| Funding Project | NSFC Basic Science Center Program for 'Multiscale Problems in Nonlinear Mechanics'[11988102] ; National Natural Science Foundation of China[21973040] ; National Natural Science Foundation of China[21504038] ; National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102] ; Youth Innovation Promotion Association CAS and Opening Fund of State Key Laboratory of Nonlinear Mechanics ; Fundamental Research Funds for the Central Universities[14380228] ; Shenzhen Science and Technology Innovation Committee[JCYJ20200109150656717] ; Shenzhen Science and Technology Innovation Committee[JCYJ20170818110613113] ; National Science Center, Poland[2016/21/B/NZ1/00006] |
| Funding Organization | NSFC Basic Science Center Program for 'Multiscale Problems in Nonlinear Mechanics' ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS and Opening Fund of State Key Laboratory of Nonlinear Mechanics ; Fundamental Research Funds for the Central Universities ; Shenzhen Science and Technology Innovation Committee ; National Science Center, Poland |
| Classification | 二类/Q1 |
| Ranking | 1 |
| Contributor | Hu, Jinglei ; Rozycki, Bartosz |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/86516 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; 2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; 3.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing 210023, Peoples R China; 4.Nanjing Univ, Inst Brain Sci, Nanjing 210023, Peoples R China; 5.Polish Acad Sci, Inst Phys, Al Lotnikow 32-46, Warsaw, Poland; 6.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China; 7.Zhejiang Univ Technol, Coll Mech Engn, Hangzhou 310023, Peoples R China; 8.Nanjing Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China |
| Recommended Citation GB/T 7714 | Li L,Hu, Jinglei,Rozycki, Bartosz,et al. Influence of lipid rafts on pattern formation during T-cell adhesion[J]. NEW JOURNAL OF PHYSICS,2021,23,4,:14.Rp_Au:Hu, Jinglei, Rozycki, Bartosz |
| APA | 李龙,Hu, Jinglei,Rozycki, Bartosz,王小环,Wu, Helong,&宋凡.(2021).Influence of lipid rafts on pattern formation during T-cell adhesion.NEW JOURNAL OF PHYSICS,23(4),14. |
| MLA | 李龙,et al."Influence of lipid rafts on pattern formation during T-cell adhesion".NEW JOURNAL OF PHYSICS 23.4(2021):14. |
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| Jp2021194.pdf（8979KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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