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| Interplay of Nanoparticle Properties during Endocytosis | |
Wang XH(王小环)1,2,3; Li L(李龙)1,2; Song F(宋凡)1,2,3
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| Corresponding Author | Li, Long(lilong@lnm.imech.ac.cn) |
| Source Publication | CRYSTALS (IF:2.061[JCR-2018],2.086[5-Year]) |
| 2021-07-01 | |
| Volume | 11Issue:7Pages:13 |
| Abstract | Nanoparticles (NPs) have been widely applied as drug carriers in drug delivery, due to their unique physical and structural properties. To achieve the drug delivery purpose, receptor-mediated endocytosis is a primary explored mechanism to internalize NPs into tumor cells. During the endocytosis process, properties of NPs, including size, shape, and surface functionality, play an important role in determining the final drug delivery efficacy. Many of these NP properties have been extensively explored individually. However, the multiple NP properties naturally interplay with each other in the endocytosis process to determine the internalization efficiency together. Therefore, it is significantly important to understand the interplay of different NP properties to improve the NP's final delivery efficacy. In this review, we focus on the interplay of NPs properties on the endocytosis process to summarize the relevant experimental observations and physical mechanisms. Particularly, three different aspects are discussed in detail, including the interplay between size and shape; size and elasticity; shape and elasticity. We have summarized the most recent works and highlighted that building up systematic understandings for the complex interplay between NP properties can greatly help a better design of NP platforms for drug delivery. |
| Keyword | nanoparticle endocytosis nanoparticle properties |
| DOI | 10.3390/cryst11070728 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000676577300001 |
| WOS Keyword | RECEPTOR-LIGAND BINDING ; CELLULAR UPTAKE ; DRUG-DELIVERY ; PEGYLATED NANOPARTICLES ; SURFACE-CHEMISTRY ; SIZE ; SHAPE ; STIFFNESS ; PENETRATION ; PHARMACOKINETICS |
| WOS Research Area | Crystallography ; Materials Science |
| WOS Subject | Crystallography ; Materials Science, Multidisciplinary |
| Funding Project | NSFC Basic Science Center Program[11988102] ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102] |
| Funding Organization | NSFC Basic Science Center Program ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| Classification | 二类 |
| Ranking | 1 |
| Contributor | Li, Long |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/87075 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; 2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; 3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Wang XH,Li L,Song F. Interplay of Nanoparticle Properties during Endocytosis[J]. CRYSTALS,2021,11,7,:13.Rp_Au:Li, Long |
| APA | 王小环,李龙,&宋凡.(2021).Interplay of Nanoparticle Properties during Endocytosis.CRYSTALS,11(7),13. |
| MLA | 王小环,et al."Interplay of Nanoparticle Properties during Endocytosis".CRYSTALS 11.7(2021):13. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Jp2021F249.pdf（3042KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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