| Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers | |
Liu Y(刘杨); Zheng X(郑旭); Guan DS(关东石); Jiang XK(蒋玺恺); Hu GQ(胡国庆)
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| Source Publication | ACS NANO
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| 2022-12 | |
| ISSN | 1936-0851 |
| Abstract | The diffusion and mobility in biomembranes are crucial for various cell functions; however, the mechanisms involved in such processes remain ambiguous due to the complex membrane structures. Herein, we investigate how the heterogeneous nanostructures cause anomalous diffusion in dipalmitoylphosphatidylcholine (DPPC) monolayers. By identifying the existence of condensed nanodomains and clarifying their impact, our findings renew the understanding of the hydrodynamic description and the statistical feature of the diffusion in the monolayers. We find a universal characteristic of the multistage mean square displacement (MSD) with an intermediate crossover, signifying two membrane viscosities at different scales: the short-time scale describes the local fluidity and is independent of the nominal DPPC density, and the long-time scale represents the global continuous phase taking into account nanodomains and increases with DPPC density. The constant short-time viscosity reflects a dynamic equilibrium between the continuous fluid phase and the condensed nanodomains in the molecular scale. Notably, we observe an anomalous yet Brownian phenomenon exhibiting an unusual double-peaked displacement probability distribution (DPD), which is attributed to the net dipolar repulsive force from the heterogeneous nanodomains around the microdomains. The findings provide physical insights into the transport of membrane inclusions that underpin various biological functions and drug deliveries. |
| Keyword | Anomalous diffusion Lipid membrane Nanodomain Anomalous yet Brownian Heterogeneity |
| Subject Area | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| DOI | 10.1021/acsnano.2c04089 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000861379100001 |
| Funding Organization | National Natural Science Foundation of China [11832017, 12072350, 11972351, 12102456] ; Chinese Academy of Sciences Key Research Program of Frontier Sciences [QYZDB-SSW-JSC036] ; Chinese Academy of Sciences Strategic Priority Research Program [XDB22040403] |
| Classification | 一类 |
| Ranking | 1 |
| Contributor | Hu, GQ (corresponding author), Zhejiang Univ, Dept Engn Mech, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310027, Peoples R China. |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/90133 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China 2.China Univ Min & Technol, Frontier Sci Res Ctr Fluidized Min Deep Undergrou, Xuzhou 221116, Jiangsu, Peoples R China 3.Zhejiang Univ, Dept Engn Mech, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310027, Peoples R China |
| Recommended Citation GB/T 7714 | Liu Y,Zheng X,Guan DS,et al. Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers[J]. ACS NANO,2022.Rp_Au:Hu, GQ (corresponding author), Zhejiang Univ, Dept Engn Mech, State Key Lab Fluid Power & Mechatron Syst, Hangzhou 310027, Peoples R China. |
| APA | 刘杨,郑旭,关东石,蒋玺恺,&胡国庆.(2022).Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers.ACS NANO. |
| MLA | 刘杨,et al."Heterogeneous Nanostructures Cause Anomalous Diffusion in Lipid Monolayers".ACS NANO (2022). |
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| File Name/Size | DocType | Version | Access | License | ||
| Jp2022FA020.pdf（5770KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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