| Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer | |
Li N(李宁) ; Zhang XY(张晓宇); Zhou J(周瑾); Li W(李旺); Shu XY(舒芯钰); Wu Y(武亿); Long M(龙勉)
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| Source Publication | ADVANCED DRUG DELIVERY REVIEWS
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| 2022-09 | |
| Volume | 188Pages:114448 |
| ISSN | 0169-409X |
| Abstract | A growing body of multiscale biomechanical studies has been proposed to highlight the mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level, changes in mechanical microen-vironment induce phenotypic and functional alterations of hepatic cells, initiating a positive feedback loop that promotes liver fibrogenesis and hepatocarcinogenesis. Tumor mechanical microenvironment of hepatocellular carcinoma facilitates tumor cell growth and metastasis, and hinders the drug delivery and immunotherapy. At the molecular level, mechanical forces are sensed and transmitted into hepatic cells via allosteric activation of mechanoreceptors on the cell membrane, leading to the activation of var-ious mechanotransduction pathways including integrin and YAP signaling and then regulating cell func-tion. Thus, the application of mechanomedicine concept in the treatment of liver diseases is promising for rational design and cell-specific delivery of therapeutic drugs. This review mainly discusses the correla-tion between biomechanical cues and liver diseases from the viewpoint of mechanobiology.(c) 2022 Elsevier B.V. All rights reserved. |
| Keyword | Liver tissue stiffness Shear stress Hydrostatic pressure Hepatocytes Hepatocellular carcinoma Liver sinusoidal endothelial cells Hepatic stellate cells Mechanotransduction pathways Mechanomedicine Drug design and delivery |
| Subject Area | Pharmacology & Pharmacy |
| DOI | 10.1016/j.addr.2022.114448 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000853367300001 |
| Funding Organization | National Natural Science Founda- tion of China [32130061, 31627804, 31870930] ; Scientific Instrument Developing Project of Chinese Academy of Sciences [GJJSTU20220002, GJJSTU20190005] |
| Classification | 一类 |
| Ranking | 1 |
| Contributor | Long, M (corresponding author), Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China. |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/90140 |
| Collection | 微重力重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Natl Micrograv Lab, Ctr Biomech & Bioengn, Key Lab Micrograv, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Li N,Zhang XY,Zhou J,et al. Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer[J]. ADVANCED DRUG DELIVERY REVIEWS,2022,188:114448.Rp_Au:Long, M (corresponding author), Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China. |
| APA | 李宁.,张晓宇.,周瑾.,李旺.,舒芯钰.,...&龙勉.(2022).Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer.ADVANCED DRUG DELIVERY REVIEWS,188,114448. |
| MLA | 李宁,et al."Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer".ADVANCED DRUG DELIVERY REVIEWS 188(2022):114448. |
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| Jp2022FA165_2022_Mul（2553KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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