| Interplay of receptor-ligand binding and lipid domain formation during cell adhesion | |
Li L(李龙) ; Hu, Jinglei1; Rozycki, Bartosz4; Ji, Jing5; Song F(宋凡)
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| Source Publication | FRONTIERS IN MOLECULAR BIOSCIENCES
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| 2022-09 | |
| Volume | 9Pages:1019477 |
| Abstract | Cell adhesion involved in biological processes such as cell migration, immune responses, and cancer metastasis, is mediated by the specific binding of receptor and ligand proteins. Some of these proteins exhibit affinity for nanoscale lipid clusters in cell membranes. A key question is how these nanoscale lipid clusters influence and react to the receptor-ligand binding during cell adhesion. In this article, we review recent computational studies that shed new light on the interplay of the receptor-ligand binding and the formation of lipid domains in adhering membranes. These studies indicate that the receptor- ligand binding promotes coalescence of lipid clusters into mesoscale domains, which, in turn, enhances both the affinity and cooperativity of the receptor-ligand binding in cell-cell adhesion with mobile ligands. In contrast, in the case of cell-extracellular matrix adhesion with immobile ligands, the receptor- ligand binding and the lipid cluster coalescence can be correlated or anti-correlated, depending strongly on the ligand distribution. These findings deepen our understanding of correlations between cell adhesion and membrane heterogeneities. |
| Keyword | cell adhesion receptor-tigand binding lipid domain formation binding affinity binding cooperativity phase separation |
| Subject Area | Biochemistry & Molecular Biology |
| DOI | 10.3389/fmolb.2022.1019477 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000864008900001 |
| Funding Organization | National Natural Science Foundation of China [11902327, 1197204, 21973040, 12272388, 12232019, 22161132012] ; Youth In11ation Promotion Association CAS ; National Science Centre of Poland [2021/40/Q/NZ1/00017] |
| Classification | 二类/Q1 |
| Ranking | 1 |
| Contributor | Hu, JL ; Rozycki, B ; Ji, J |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/90168 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China 2.Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China 3.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China 5.Polish Acad Sci, Inst Phys, Warsaw, Poland 6.Beihang Univ, Key Lab Biomech & Mechanobiol, Minist Educ, Beijing Adv In11at Ctr Biomed Engn,Sch Biol Sci, Beijing, Peoples R China 7.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Li L,Hu, Jinglei,Rozycki, Bartosz,et al. Interplay of receptor-ligand binding and lipid domain formation during cell adhesion[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2022,9:1019477.Rp_Au:Hu, JL, Rozycki, B, Ji, J |
| APA | 李龙,Hu, Jinglei,Rozycki, Bartosz,Ji, Jing,&宋凡.(2022).Interplay of receptor-ligand binding and lipid domain formation during cell adhesion.FRONTIERS IN MOLECULAR BIOSCIENCES,9,1019477. |
| MLA | 李龙,et al."Interplay of receptor-ligand binding and lipid domain formation during cell adhesion".FRONTIERS IN MOLECULAR BIOSCIENCES 9(2022):1019477. |
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| Jp2022FA180_2022_Int（1055KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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