| Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction | |
Li L(李龙); Ji, Jing; Song F(宋凡) ; Hu, Jinglei
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| Corresponding Author | Ji, Jing([email protected]) ; Hu, Jinglei([email protected]) |
| Source Publication | JOURNAL OF MOLECULAR BIOLOGY
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| 2023-01-15 | |
| Volume | 435Issue:1Pages:17 |
| ISSN | 0022-2836 |
| Abstract | Gaining insights into the intercellular receptor-ligand binding is of great importance for understanding numerous physiological and pathological processes, and stimulating new strategies in drug design and discovery. In contrast to the in vitro protein interaction in solution, the anchored receptor and ligand mole-cules interact with membrane in situ, which affects the intercellular receptor-ligand binding. Here, we review theoretical, simulation and experimental works regarding the regulatory effects of protein -membrane interactions on intercellular receptor-ligand binding mainly from the following aspects: mem-brane fluctuations, membrane curvature, glycocalyx, and lipid raft. In addition, we discuss biomedical sig-nificances and possible research directions to advance the field and highlight the importance of understanding of coupling effects of these factors in pharmaceutical development.(c) 2022 Elsevier Ltd. All rights reserved. |
| Keyword | Protein-membrane interaction Intercellular receptor-ligand binding Membrane fluctuations and curvature Glycocalyx Lipid raft |
| DOI | 10.1016/j.jmb.2022.167787 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000913850700001 |
| WOS Keyword | ATOMIC-FORCE MICROSCOPY ; CELL-ADHESION MOLECULES ; LIPID RAFTS ; ANCHORED RECEPTORS ; PLASMA-MEMBRANE ; CURVATURE GENERATION ; SIGNALING MOLECULES ; STRUCTURAL INSIGHTS ; ELASTIC PROPERTIES ; PHYSICAL BIOLOGY |
| WOS Research Area | Biochemistry & Molecular Biology |
| WOS Subject | Biochemistry & Molecular Biology |
| Funding Project | National Natural Science Foundation of China[11902327] ; National Natural Science Foundation of China[11972041] ; National Natural Science Foundation of China[22161132012] ; National Natural Science Foundation of China[21973040] ; Youth Innovation Promotion Association CAS |
| Funding Organization | National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS |
| Classification | 二类/Q1 |
| Ranking | 1 |
| Contributor | Ji, Jing ; Hu, Jinglei |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/91576 |
| Collection | 非线性力学国家重点实验室 |
| Recommended Citation GB/T 7714 | Li L,Ji, Jing,Song F,et al. Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction[J]. JOURNAL OF MOLECULAR BIOLOGY,2023,435,1,:17.Rp_Au:Ji, Jing, Hu, Jinglei |
| APA | 李龙,Ji, Jing,宋凡,&Hu, Jinglei.(2023).Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction.JOURNAL OF MOLECULAR BIOLOGY,435(1),17. |
| MLA | 李龙,et al."Intercellular Receptor-ligand Binding: Effect of Protein-membrane Interaction".JOURNAL OF MOLECULAR BIOLOGY 435.1(2023):17. |
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| File Name/Size | DocType | Version | Access | License | ||
| Jp2023Fa171.pdf（1310KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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