Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates

doi:10.1016/j.devcel.2023.04.004

IMECH-IR > 非线性力学国家重点实验室

	Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates
	Wang, Zheng ; Yang, Chun ; Guan DS(关东石); Li, Jiaqi; Zhang, Hong
发表期刊	DEVELOPMENTAL CELL
	2023-06-05
卷号	58 期号:11 页码:919
ISSN	1534-5807
摘要	Interfacial tension governs the behaviors and physiological functions of multiple biological condensates dur-ing diverse biological processes. Little is known about whether there are cellular surfactant factors that regu-late the interfacial tension and functions of biological condensates within physiological environments. TFEB, a master transcription factor that controls expression of autophagic-lysosomal genes, assembles into tran-scriptional condensates to control the autophagy-lysosome pathway (ALP). Here, we show that interfacial tension modulates the transcriptional activity of TFEB condensates. MLX, MYC, and IPMK act as synergistic surfactants to decrease the interfacial tension and consequent DNA affinity of TFEB condensates. The inter-facial tension of TFEB condensates is quantitatively correlated to their DNA affinity and subsequent ALP ac-tivity. The interfacial tension and DNA affinity of condensates formed by TAZ-TEAD4 are also regulated by the synergistic surfactant proteins RUNX3 and HOXA4. Our results indicate that the interfacial tension and functions of biological condensates can be controlled by cellular surfactant proteins in human cells.
DOI	10.1016/j.devcel.2023.04.004
收录类别	SCI
语种	英语
WOS记录号	WOS:001011548600001
WOS研究方向	Cell Biology ; Developmental Biology
项目资助者	National Natural Science Foundation of China [82188101, 31871426]
论文分区	一类
力学所作者排名	3
RpAuthor	Wang, Z (corresponding author), Inst Biophys, Chinese Acad Sci, CAS Ctr Excellence Biomacromolecules, Natl Lab Biomacromolecules, Beijing 100101, Peoples R China.
引用统计	被引频次：13[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/92431
专题	非线性力学国家重点实验室
作者单位	1.{Wang Zheng, Yang Chun, Zhang Hong} Inst Biophys Chinese Acad Sci CAS Ctr Excellence Biomacromolecules Natl Lab Biomacromolecules Beijing 100101 Peoples R China 2.{Yang Chun, Li Jiaqi, Zhang Hong} Univ Chinese Acad Sci Coll Life Sci Beijing 100049 Peoples R China 3.{Guan Dongshi} Chinese Acad Sci Inst Mech State Key Lab Nonlinear Mech Beijing 100190 Peoples R China
推荐引用方式 GB/T 7714	Wang, Zheng,Yang, Chun,Guan DS,et al. Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates[J]. DEVELOPMENTAL CELL,2023,58,11,:919.Rp_Au:Wang, Z (corresponding author), Inst Biophys, Chinese Acad Sci, CAS Ctr Excellence Biomacromolecules, Natl Lab Biomacromolecules, Beijing 100101, Peoples R China.
APA	Wang, Zheng,Yang, Chun,关东石,Li, Jiaqi,&Zhang, Hong.(2023).Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates.DEVELOPMENTAL CELL,58(11),919.
MLA	Wang, Zheng,et al."Cellular proteins act as surfactants to control the interfacial behavior and function of biological condensates".DEVELOPMENTAL CELL 58.11(2023):919.

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