| Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling | |
| Wang, Xiaochen; Li HY(李航宇); Zheng, Yu; Guan DS(关东石); Wang, Aidan; Fan, Qihui; Jiao, Yang; Ye, Fangfu | |
| Source Publication | ADVANCED FUNCTIONAL MATERIALS
 |
| 2023-07-07 | |
| ISSN | 1616-301X |
| Abstract | Cells in vivo are surrounded by fibrous extracellular matrix (ECM), which can mediate the propagation of active cellular forces through stressed fiber bundles and regulate various biological processes. However, the mechanisms for multi-cellular organization and collective dynamics induced by cell-ECM mechanical couplings, which are crucial for the development of novel ECM-based biomaterial for cell manipulation and biomechanical applications, remain poorly understood. Herein, the authors design an in vitro quasi-3D experimental system and demonstrate a transition between spreading and aggregating in collective organizational behaviors of discrete multi-cellular systems, induced by engineered ECM-cell mechanical coupling, with the observed phenomena and underlying mechanisms differing fundamentally from those of cell monolayers. During the process of collective cell organization, the collagen substrate undergoes reconstruction into a dense fiber network structure, which is correlated with local cellular density and consistent with observed enhanced cells' motility; and the weakening of fiber bundle formation within the hydrogel reduces cells' movement. Moreover, cells can respond to the curvature and shape of the original cell population and form different aggregation patterns. These results elucidate important physical factors involved in collective cell organization and provide important references for potential applications of biomaterials in new therapies and tissue engineering. |
| Keyword | biomaterials cell organization collagen extracellular matrix mechanical coupling |
| DOI | 10.1002/adfm.202305414 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:001023448900001 |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| Funding Organization | National Key Research and Development Program of China [2022YFA1405002, 2020YFA0908200, 2021YFA0719302] ; National Natural Science Foundation of China [T2221001, 12074407, 12090054, 11972351] ; Strategic Priority Research Program of Chinese Academy of Sciences [XDB33030300] ; Youth Innovation Promotion Association of CAS [2021007] |
| Classification | 一类 |
| Ranking | 2 |
| Contributor | Ye, FF (corresponding author), Univ Chinese Acad Sci, Wenzhou Inst, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325000, Peoples R China. ; Fan, QH ; Ye, FF (corresponding author), Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China. ; Jiao, Y (corresponding author), Arizona State Univ, Mat Sci & Engn, Tempe, AZ 85287 USA. ; Jiao, Y (corresponding author), Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA. |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/92601 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.{Wang, Xiaochen, Ye, Fangfu} Univ Chinese Acad Sci, Wenzhou Inst, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325000, Peoples R China 2.{Wang, Xiaochen, Fan, Qihui, Ye, Fangfu} Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China 3.{Wang, Xiaochen, Ye, Fangfu} Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100049, Peoples R China 4.{Li, Hangyu, Guan, Dongshi} Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China 5.{Li, Hangyu, Guan, Dongshi} Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 6.{Zheng, Yu, Jiao, Yang} Arizona State Univ, Mat Sci & Engn, Tempe, AZ 85287 USA 7.{Zheng, Yu, Jiao, Yang} Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA 8.{Wang, Aidan} Aidi Sch, Beijing 100018, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Xiaochen,Li HY,Zheng, Yu,et al. Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling[J]. ADVANCED FUNCTIONAL MATERIALS,2023.Rp_Au:Ye, FF (corresponding author), Univ Chinese Acad Sci, Wenzhou Inst, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou 325000, Peoples R China., Fan, QH, Ye, FF (corresponding author), Chinese Acad Sci, Inst Phys, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China., Jiao, Y (corresponding author), Arizona State Univ, Mat Sci & Engn, Tempe, AZ 85287 USA., Jiao, Y (corresponding author), Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA. |
| APA | Wang, Xiaochen.,李航宇.,Zheng, Yu.,关东石.,Wang, Aidan.,...&Ye, Fangfu.(2023).Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling.ADVANCED FUNCTIONAL MATERIALS. |
| MLA | Wang, Xiaochen,et al."Collective Organization Behaviors of Multi-Cell Systems Induced by Engineered ECM-Cell Mechanical Coupling".ADVANCED FUNCTIONAL MATERIALS (2023). |
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| Jp2023Fa002.pdf（6634KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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