| A chemo-mechanical model for growth and mechanosensing of focal adhesion | |
Xing, Jiashi1,2; Sun, Fuqiang2 ; Lin, Yuan2,3,4; Gong, Ze1,5
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| Corresponding Author | Lin, Yuan([email protected]) ; Gong, Ze([email protected]) |
| Source Publication | JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
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| 2024-12-01 | |
| Volume | 193Pages:13 |
| ISSN | 0022-5096 |
| Abstract | Focal adhesion (FA), the complex molecular assembly across the lipid membrane, serves as a hub for physical and chemical information exchange between cells and their microenvironment. Interestingly, studies have shown that FAs can grow along the direction of contractile forces generated by actomyosin stress fibers and achieve larger sizes on stiffer substrates. In addition, the cellular traction transmitted to the substrate was observed to reach the maximum near the FA center. However, the biomechanical mechanisms behind these intriguing findings remain unclear. To answer this important question, here we first developed a one-dimensional (1D) chemo-mechanical model of FA where key features like adhesion plaque deformation, active contraction by stress fibers, force-dependent association/dissociation of integrin bonds connecting two surfaces, and substrate compliance have all been considered. Within this formulation, we showed that the rigidity-sensing capability of FAs originates from the deformability of stress fibers while the force-dependent breakage of integrin bonds leads to the appearance of the traction peak at the FA center. Furthermore, by extending the model into three-dimensional as well as incorporating assembly/dis-assembly kinetics of adhesion proteins, we also demonstrated how anisotropic stress/strain field within the adhesion plaque will be induced by the presence of contractile forces which leads to the directional growth of the FA. |
| Keyword | Focal adhesion (FA) Mechano-sensing Cellular traction Active contraction |
| DOI | 10.1016/j.jmps.2024.105863 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:001318903200001 |
| WOS Keyword | CELL-ADHESION ; NANOSCALE ARCHITECTURE ; MATRIX ADHESIONS ; MECHANICAL MODEL ; STRESS FIBER ; FORCE ; STIFFNESS ; DYNAMICS ; CONTRACTILITY ; ELASTICITY |
| WOS Research Area | Materials Science ; Mechanics ; Physics |
| WOS Subject | Materials Science, Multidisciplinary ; Mechanics ; Physics, Condensed Matter |
| Funding Project | National Natural Science Foundation of China[12202439] ; National Natural Science Foundation of China[12272332] ; USTC Research Funds of the Double First-Class Initiative[YD2090002012] ; Research Grants Council of Hong Kong under the General Research Fund[16205619] ; Research Grants Council of Hong Kong under the General Research Fund[17210520] ; Health@InnoHK program of the Innovation and Technology Commission of the Hong Kong SAR Government |
| Funding Organization | National Natural Science Foundation of China ; USTC Research Funds of the Double First-Class Initiative ; Research Grants Council of Hong Kong under the General Research Fund ; Health@InnoHK program of the Innovation and Technology Commission of the Hong Kong SAR Government |
| Classification | 一类/力学重要期刊 |
| Ranking | 1 |
| Contributor | Lin, Yuan ; Gong, Ze |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/96758 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Univ Sci & Technol China, Dept Modern Mech, Key Lab Mech Behav & Design Mat, CAS, Hefei 230027, Anhui, Peoples R China; 2.Univ Hong Kong, Dept Mech Engn, Hong Kong, Peoples R China; 3.HKU Shenzhen Inst Res & Innovat, Shenzhen, Guangdong, Peoples R China; 4.Adv Biomed Instrumentat Ctr, Shatin, Hong Kong Sci Pk, Hong Kong, Peoples R China; 5.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, 15 Beisihuan West Rd, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Xing, Jiashi,Sun, Fuqiang,Lin, Yuan,et al. A chemo-mechanical model for growth and mechanosensing of focal adhesion[J]. JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS,2024,193:13.Rp_Au:Lin, Yuan, Gong, Ze |
| APA | Xing, Jiashi,Sun, Fuqiang,Lin, Yuan,&Gong, Ze.(2024).A chemo-mechanical model for growth and mechanosensing of focal adhesion.JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS,193,13. |
| MLA | Xing, Jiashi,et al."A chemo-mechanical model for growth and mechanosensing of focal adhesion".JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS 193(2024):13. |
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