| Effects of boundary conditions on the transmitral pressure gradient for numerical simulation of flow in a left heart model | |
Wu F(吴凡); Feng, Shuyi; He XY(何心怡); Wang HP(王洪平); Kong, Pengxu; Wei, Peijian; Pan, Xiangbin; Wang SZ(王士召)
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| Source Publication | PHYSICS OF FLUIDS
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| 2024-11 | |
| Volume | 36Issue:11Pages:111908 |
| ISSN | 1070-6631 |
| Abstract | The transmitral pressure gradient is a crucial clinical indicator for diagnosing mitral regurgitation and stenosis. Numerical simulation of specific patients can obtain the complete pressure distribution in the left heart system, which is an important approach to evaluate cardiac function. However, the results are sensitive to the boundary conditions used in the numerical simulations. In the present work, we constructed a left heart model and assessed the effects of four typical boundary conditions on the transmitral pressure gradient, which is computed based on the Bernoulli equation and the line probe, respectively. The results show that the transmitral pressure gradient obtained by the line probe is sensitive to the boundary conditions. The sensitivity is closely related to the pressure in the atrium but has negligible effect on the pressure in the ventricle. This study sheds light on evaluating the pressure gradient of patient-specific treatments based on the numerical simulation of a left heart model. |
| DOI | 10.1063/5.0228808 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:001351098700010 |
| WOS Research Area | Mechanics ; Physics |
| WOS Subject | Mechanics ; Physics, Fluids & Plasmas |
| Funding Organization | National Natural Science Foundation of China10.13039/501100001809 {11988102] ; NSFC Basic Science Center Program {92252203, 12072348] ; National Natural Science Foundation of China {YSBR-087] ; Chinese Academy of Sciences Project for Young Scientists in Basic Research {2019PT350005] ; Fundamental Research Funds for the Central Universities {2021-I2M-1-065] ; CAMS Innovation Fund for Medical Sciences |
| Classification | 一类/力学重要期刊 |
| Ranking | 1 |
| Contributor | Wang SZ ; Pan XB |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/97220 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.【Wu, Fan & He, Xinyi & Wang, Hongping & Wang, Shizhao】 Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China 2.【Wu, Fan & He, Xinyi & Wang, Hongping & Wang, Shizhao】 Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China 3.【Feng, Shuyi & Kong, Pengxu & Wei, Peijian & Pan, Xiangbin】 Chinese Acad Med Sci Peking Union Med Coll, China & Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Struct Heart Dis, Beijing 100037, Peoples R China 4.【Feng, Shuyi & Kong, Pengxu & Wei, Peijian & Pan, Xiangbin】 Natl Hlth Commiss Key Lab Cardiovasc Regenerat Med, Beijing 100037, Peoples R China 5.【Feng, Shuyi & Kong, Pengxu & Wei, Peijian & Pan, Xiangbin】 Chinese Acad Med Sci, Key Lab Innovat Cardiovasc Devices, Beijing 100037, Peoples R China 6.【Kong, Pengxu & Wei, Peijian & Pan, Xiangbin】 Chinese Acad Med Sci, Fuwai Hosp, Natl Clin Res Ctr Cardiovasc Dis, Beijing 100037, Peoples R China |
| Recommended Citation GB/T 7714 | Wu F,Feng, Shuyi,He XY,et al. Effects of boundary conditions on the transmitral pressure gradient for numerical simulation of flow in a left heart model[J]. PHYSICS OF FLUIDS,2024,36,11,:111908.Rp_Au:Wang SZ, Pan XB |
| APA | 吴凡.,Feng, Shuyi.,何心怡.,王洪平.,Kong, Pengxu.,...&王士召.(2024).Effects of boundary conditions on the transmitral pressure gradient for numerical simulation of flow in a left heart model.PHYSICS OF FLUIDS,36(11),111908. |
| MLA | 吴凡,et al."Effects of boundary conditions on the transmitral pressure gradient for numerical simulation of flow in a left heart model".PHYSICS OF FLUIDS 36.11(2024):111908. |
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