| Magnetic soft microfiberbots for robotic embolization | |
| Liu, Xurui; 王柳, Liu; Xiang, Yuanzhuo; Liao, Fan; Li, Na; Li, Jiyu; Wang, Jiaxin; Wu, Qingyang; Zhou, Cheng; Yang, Youzhou; Kou, Yuanshi; Yang, Yueying; Tang, Hanchuan; Zhou, Ning; Wan, Chidan; Yin, Zhouping; Yang, GuangZhong; Tao, Guangming; Zang, Jianfeng | |
| Source Publication | SCIENCE ROBOTICS
 |
| 2024-04 | |
| Volume | 9Issue:87Pages:eadh2479 |
| ISSN | 2470-9476 |
| Abstract | Cerebral aneurysms and brain tumors are leading life-threatening diseases worldwide. By deliberately occluding the target lesion to reduce the blood supply, embolization has been widely used clinically to treat cerebral aneurysms and brain tumors. Conventional embolization is usually performed by threading a catheter through blood vessels to the target lesion, which is often limited by the poor steerability of the catheter in complex neurovascular networks, especially in submillimeter regions. Here, we propose magnetic soft microfiberbots with high steerability, reliable maneuverability, and multimodal shape reconfigurability to perform robotic embolization in submillimeter regions via a remote, untethered, and magnetically controllable manner. Magnetic soft microfiberbots were fabricated by thermal drawing magnetic soft composite into microfibers, followed by magnetizing and molding procedures to endow a helical magnetic polarity. By controlling magnetic fields, magnetic soft microfiberbots exhibit reversible elongated/aggregated shape morphing and helical propulsion in flow conditions, allowing for controllable navigation through complex vasculature and robotic embolization in submillimeter regions. We performed in vitro embolization of aneurysm and tumor in neurovascular phantoms and in vivo embolization of a rabbit femoral artery model under real-time fluoroscopy. These studies demonstrate the potential clinical value of our work, paving the way for a robotic embolization scheme in robotic settings. |
| DOI | 10.1126/scirobotics.adh2479 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:001173750800002 |
| WOS Research Area | Robotics |
| WOS Subject | Robotics |
| Funding Organization | National Natural Science Foundation of China {52188102, 51820105008, 51572096, 2022YFC2408100, 11272369, 62175082] ; Huazhong University of Science and Technology Interdisciplinary Research Support Program {2023JCYJ044, 2023JCYJ039] |
| Classification | 一类 |
| Ranking | 2 |
| Contributor | Zang JF ; Tao GM ; Yang GZ |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/97246 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.【Liu, Xurui & Liao, Fan & Li, Na & Wu, Qingyang & Zhou, Cheng & Yang, Youzhou & Kou, Yuanshi & Yang, Yueying & Tang, Hanchuan & Zang, Jianfeng】 Huazhong Univ Sci & Technol, Sch Integrated Circuits, Wuhan 430074, Peoples R China 2.【Liu, Xurui & Xiang, Yuanzhuo & Liao, Fan & Li, Na & Wu, Qingyang & Zhou, Cheng & Yang, Youzhou & Kou, Yuanshi & Yang, Yueying & Tang, Hanchuan & Tao, Guangming & Zang, Jianfeng】 Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 3.【Wang, Liu & Li, Jiyu】 Univ Sci & Technol China, Dept Modern Mech, CAS Key Lab Mech Behav & Design Mat, Hefei 230026, Peoples R China 4.【Wang, Liu】 Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, 15 Beisihuan West Rd, Beijing 100190, Peoples R China 5.【Wang, Jiaxin】 Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Urol, Wuhan 430030, Peoples R China 6.【Zhou, Ning】 Huazhong Univ Sci & Technol, Dept Internal Med, Div Cardiol, Tongji Med Coll,Tongji Hosp, Wuhan 430074, Peoples R China 7.【Wan, Chidan】 Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hepatobiliary Surg, Wuhan 430074, Peoples R China 8.【Yin, Zhouping】 Huazhong Univ Sci & Technol, Flexible Elect Res Ctr, Sch Mech Sci & Engn, State Key Lab Digital Mfg Equipment & Technol, Wuhan 430074, Hubei, Peoples R China 9.【Yin, Zhouping & Zang, Jianfeng】 Huazhong Univ Sci & Technol, Sch Mech Sci & Engn, State Key Lab Intelligent Mfg Equipment & Technol, Wuhan 430074, Peoples R China 10.【Yang, Guang-Zhong】 Shanghai Jiao Tong Univ, Inst Med Robot, Shanghai 200240, Peoples R China 11.【Tao, Guangming】 Huazhong Univ Sci & Technol, Sch Mat Sci & Engn, State Key Lab Mat Proc & Die & Mould Technol, Wuhan 430074, Peoples R China 12.【Tao, Guangming】 Huazhong Univ Sci & Technol, Tongji Hosp, Key Lab Vasc Aging, Minist Educ,Tongji Med Coll, Wuhan 430030, Peoples R China 13.【Tao, Guangming】 Huazhong Univ Sci & Technol, Inst Med Equipment Sci & Engn, Wuhan 430074, Hubei, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Xurui,王柳, Liu,Xiang, Yuanzhuo,et al. Magnetic soft microfiberbots for robotic embolization[J]. SCIENCE ROBOTICS,2024,9,87,:eadh2479.Rp_Au:Zang JF, Tao GM, Yang GZ |
| APA | Liu, Xurui.,王柳, Liu.,Xiang, Yuanzhuo.,Liao, Fan.,Li, Na.,...&Zang, Jianfeng.(2024).Magnetic soft microfiberbots for robotic embolization.SCIENCE ROBOTICS,9(87),eadh2479. |
| MLA | Liu, Xurui,et al."Magnetic soft microfiberbots for robotic embolization".SCIENCE ROBOTICS 9.87(2024):eadh2479. |
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