Lattice-based mesoscale simulations and mean-field theory of cell membrane adhesion

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	Lattice-based mesoscale simulations and mean-field theory of cell membrane adhesion
	Li L(李龙); Gao J; Milewski L; Hu JL; Różycki B
	2024-07-16
摘要	Adhesion of cell membranes involves multi-scale phenomena, ranging from specific molecular binding at Angstrom scale all the way up to membrane deformations and phase separation at micrometer scale. Consequently, theory and simulations of cell membrane adhesion require multi-scale modeling and suitable approximations that capture the essential physics of these phenomena. Here, we present a mesoscale model for membrane adhesion which we have employed in a series of our recent studies. This model quantifies, in particular, how nanoscale lipid clusters physically affect and respond to the intercellular receptor-ligand binding that mediates membrane adhesion. The goal of this Chapter is to present all details and subtleties of the mean-field theory and Monte Carlo simulations of this mesoscale model, which can be used to further explore physical phenomena related to cell membrane adhesion.
专著/编著/文集名	Methods in Enzymology
页码	425-455
出版者	Elsevier
语种	英语
文献类型	图书章节
条目标识符	http://dspace.imech.ac.cn/handle/311007/97475
专题	非线性力学国家重点实验室
通讯作者	Hu JL; Różycki B
推荐引用方式 GB/T 7714	Li L,Gao J,Milewski L,et al. Lattice-based mesoscale simulations and mean-field theory of cell membrane adhesion[Ch]. Methods in Enzymology,Elsevier,2024.