| Single ion detection method and device | |
Liu W(刘巍) ; Niu Y(牛宇); Luo ZR(罗子人)
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| 2023-11-07 | |
| Rights Holder | INSTITUTE OF MECHANICS, CHINESE ACADEMY OF SCIENCES |
| Abstract | A single ion imaging-based detection method and device are provided. After being reflected by an electromodulation singularity coupling differential imaging reaction unit, a probe beam from a total internal reflection ellipsometry imager converges on a CCD or CMOS detector, the acquired sensing surface image data is transmitted to a signal processing unit, the common mode noise is eliminated by performing spectral analysis on differential signals of a working sensing surface and a reference sensing surface, the peak intensity of a modulating signal is selected on the spectrum for wave filtering to obtain a real-time signal of interaction of single ions or charged molecules at a solid-liquid interface. Based on the singularity effect at a surface plasma resonance angle of an ellipsometry phase and a corresponding optical signal noise suppression scheme, the present application can achieve real-time observation of the adsorption of single ions or charged molecules at a solid surface. |
| Application Date | 2022-03-22 |
| Application Number | US18019485 |
| Patent Number | US11808695B2 |
| Claim | 1. A single ion imaging detection method, comprising: (1) applying, by a signal generator (3), a high-frequency sinusoidal modulating signal to a working sensing surface (W1) of an electromodulation singularity coupling differential imaging reaction unit (2), wherein the signal generator comprises a positive pole (31) connected to a sensing surface (W1) of a working unit (21) and a negative pole (32) connected to a platinum wire counter electrode (22) of the working unit and is configured to apply a sinusoidal modulating signal to the surface of the working unit; (2) after a probe beam from a total internal reflection ellipsometry imager (1) is reflected by the electromodulation singularity coupling differential imaging reaction unit (2), converging the probe beam on a detector of the total internal reflection ellipsometry imager (1), (3) transmitting sensing surface image data acquired via a CCD or CMOS detector to a signal processing unit (4), and (4) selecting, by the signal processing unit (4), area images of a same size on the working sensing surface and a reference sensing surface (R2) in the electromodulation singularity coupling differential imaging reaction unit (2), so as to obtain a working area signal intensity I0(t) and its mean value Ī0, a reference area signal intensity Ir(t) and its mean value Īr within a specific integration time, carrying out a S=I0(t)-I0_Ir_(Ir(t)-Ir_) inversion to calculate a differential signal S of a single ion or a charged molecule at a solid-liquid interface on the working sensing surface (W1) of the electromodulation singularity coupling differential imaging reaction unit, carrying out a Fourier transform on the differential signal S, and selecting a peak of a modulating signal on a spectrum for filtering and a noise reduction. |
| Language | 英语 |
| Classification | 发明授权 |
| Status | 有效 |
| Note | 授权 |
| Country | 美国 |
| Agency | 北京和信华成知识产权代理事务所 |
| Document Type | 专利 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/99969 |
| Collection | 微重力重点实验室 |
| Recommended Citation GB/T 7714 | Liu W,Niu Y,Luo ZR. Single ion detection method and device. US11808695B2[P]. 2023-11-07. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| US11808695B2.pdf（526KB） | 专利 | 开放获取 | CC BY-NC-SA | View Download | ||
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