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Mechanical strength determines Ca2+ transients triggered by the engagement of beta(2) integrins to their ligands 期刊论文
EXPERIMENTAL CELL RESEARCH, 2020, 卷号: 387, 期号: 2, 页码: 7./通讯作者：Long, Mian
作者:  Shu XY(舒芯钰);  Li N(李宁);  Huang DD(黄丹丹);  Zhang Y(章燕);  Lv SQ(吕守芹);  Long M(龙勉)
浏览  |  Adobe PDF(1108Kb)  |  收藏  |  浏览/下载：590/225  |  提交时间：2020/04/07
beta(2) integrin  Ligands  Calcium transients  Bond strength  Mechanotransduction  Shear stress  
Mechanical Strength and Structural Basis of beta(2) Integrin to Mediate Neutrophil Accumulation on Liver Sinusoidal Endothelial Cells: A Study Using Atomic Force Microscopy and Molecular Dynamics Simulations 期刊论文
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES, 2018, 卷号: 116, 期号: 2, 页码: 263-279
作者:  Li N(李宁);  Zhang X(张潇);  Li PW;  Yang H;  Tong CF;  Lv SQ(吕守芹);  Zhang Y(章燕);  Ye ZY;  Pan J;  Long M(龙勉)
浏览  |  Adobe PDF(865Kb)  |  收藏  |  浏览/下载：488/227  |  提交时间：2018/10/30
Liver sinusoidal endothelial cells  neutrophils  beta(2) integrin  shear flow  mechanical strength  
Salt bridge interactions within the beta(2) integrin alpha(7) helix mediate force-induced binding and shear resistance ability 期刊论文
FEBS JOURNAL, 2018, 卷号: 285, 期号: 2, 页码: 261-274
作者:  Zhang X(张潇);  Li LD;  Li N(李宁);  Shu XY;  Zhou LW(周吕文);  Lv SQ(吕守芹);  Chen SB;  Mao DB;  Long M(龙勉)
浏览  |  Adobe PDF(2053Kb)  |  收藏  |  浏览/下载：346/102  |  提交时间：2018/10/30
beta(2) integrin  allostery  conformational stability  force  salt bridge interaction  
Spreading of human neutrophils on an ICAM-1-immobilized substrate under shear flow 期刊论文
CHINESE SCIENCE BULLETIN, 2012, 卷号: 57, 期号: 7, 页码: 769-775
作者:  Zhan DY(展冬颖);  Zhang Y(章燕);  Long M(龙勉);  Long, MA;  Chinese Acad Sci, Inst Mech, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China.
Adobe PDF(685Kb)  |  收藏  |  浏览/下载：1069/270  |  提交时间：2013/01/18
Neutrophil  Spreading  Beta 2 Integrin  Icam-1  Shear Stress  Cell-surface Adhesion  L-selectin  Polymorphonuclear Leukocytes  Endothelial-cells  Rolling Adhesions  P-selectin  Integrin  Affinity  Stress  Icam-1  
Modeling of Cell Aggregation Dynamics Governed by Receptor-Ligand Binding Under Shear Flow 期刊论文
Cellular and Molecular Bioengineering, 2011, 卷号: 4, 期号: 3, 页码: 427-441
作者:  Fu ZL(傅长亮);  Tong CF(佟春芳);  Dong C;  Long M(龙勉);  Long, M (reprint author), Chinese Acad Sci, Key Lab Micrograv, Inst Mech, Beijing 100190, Peoples R China
Adobe PDF(2624Kb)  |  收藏  |  浏览/下载：1321/315  |  提交时间：2012/04/01
Two-dimensional Kinetics  Cone-plate Viscometer  Homotypic Aggregation  Heterotypic Aggregation  Bell Model  Protein G-igg Bond  Beta(2)-integrin And Icam-1 Bond  Human Blood-platelets  Intercellular-adhesion Molecule-1  Hydrodynamic Shear  Disaggregation Kinetics  Neutrophil Aggregation  Sequential Binding  Mediated Adhesion  Stable Adhesion  Melanoma-cells  Latex Spheres  
Beta2整合素及其配体相互作用的二维反应动力学研究 学位论文
博士论文，北京: 中国科学院研究生院, 2009
作者:  付长亮
Adobe PDF(3738Kb)  |  收藏  |  浏览/下载：711/1  |  提交时间：2011/12/30
Beta2整合素  Icam-1  二维反应动力学  黑色素瘤细胞  Pmn  内皮细胞  肿瘤转移  锥板粘度计  细胞聚集  概率动力学模型  微管吸吮技术 其他语种关键词 beta2-integrin  Icam-1  2d Kinetics  Melanoma  Polymorphonuclear Neutrophil (Pmn)  Endothelial (Ec)  Tumor Metastasis  Cone-plate Viscometer  Cell Aggregation  Probabilistic Kinetics Model  Micropipette Aspiration Techenique (Mat)