| Simulated pathogenic conformational switch regions matched well with the biochemical findings | |
Liu X(刘鑫) ; Zhao YP(赵亚溥)
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| Source Publication | Journal of Biomedical Informatics.
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| 2010 | |
| Volume | 43Issue:3Pages:365-375 |
| ISSN | 1532-0464 |
| Abstract | Pathogenic conformational conversion is a general causation of many disease, such as transmissible spon- giform encephalopathy (TSE) caused by misfolding of prion, sickle cell anemia, and etc. In such structural changes, misfolding occurs in regions important for the stability of native structure firstly. This destabi- lizes the normal conformation and leads to subsequent errors in folding pathway. Sites involved in the first stage can be deemed switch regions of the protein, and are vital for conformational conversion. Namely it could be a switch of disease at residue level. Here we report an algorithm that can identify such sites computationally with an accuracy of 93%, by calculating the probability of the native structure of a short segment jumping to a mistake one. Knowledge of such switch sites could be used to target clinical therapy, study physiological and pathologic mechanism of protein, and etc. |
| Subject Area | 生物力学 |
| DOI | 10.1016/j.jbi.2009.12.003 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000278780800003 |
| WOS Keyword | AMYLOID FIBRIL FORMATION ; APOLIPOPROTEIN-A-I ; CRYSTAL-STRUCTURE ; CYSTATIN-C ; DISEASE ; PROTEIN ; TRANSTHYRETIN ; AGGREGATION ; PREDICTION ; SEQUENCE |
| WOS Research Area | Computer Science ; Medical Informatics |
| WOS Subject | Computer Science, Interdisciplinary Applications ; Medical Informatics |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/33080 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Zhao YP(赵亚溥) |
| Recommended Citation GB/T 7714 | Liu X,Zhao YP. Simulated pathogenic conformational switch regions matched well with the biochemical findings[J]. Journal of Biomedical Informatics.,2010,43,3,:365-375. |
| APA | 刘鑫,&赵亚溥.(2010).Simulated pathogenic conformational switch regions matched well with the biochemical findings.Journal of Biomedical Informatics.,43(3),365-375. |
| MLA | 刘鑫,et al."Simulated pathogenic conformational switch regions matched well with the biochemical findings".Journal of Biomedical Informatics. 43.3(2010):365-375. |
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