| Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels | |
Sun JS ; Liu C(刘超); Li MM; Wang JD; Xianyu YL; Hu GQ(胡国庆); Jiang XY; Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China.
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| Source Publication | BIOMICROFLUIDICS
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| 2013-02-04 | |
| Volume | 7Issue:1Pages:011802/1-011802/11 |
| ISSN | 1932-1058 |
| Abstract | In this work, we propose a rapid and continuous rare tumor cell separation based on hydrodynamic effects in a label-free manner. The competition between the inertial lift force and Dean drag force inside a double spiral microchannel results in the size-based cell separation of large tumor cells and small blood cells. The mechanism of hydrodynamic separation in curved microchannel was investigated by a numerical model. Experiments with binary mixture of 5- and 15-mu m-diameter polystyrene particles using the double spiral channel showed a separation purity of more than 95% at the flow rate above 30 ml/h. High throughput (2.5 x 10(8) cells/min) and efficient cell separation (more than 90%) of spiked HeLa cells and 20 x diluted blood cells was also achieved by the double spiral channel. |
| Keyword | Biomems Cellular Biophysics Hydrodynamics Microchannel Flow Tumours |
| Subject Area | 微机电系统中的流体力学问题 |
| URL | 查看原文 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000315597100008 |
| Funding Organization | MOST [2011CB933201, 2009CB930001, 2011CB707604]; NSFC [51105086, 21025520, 90813032, 50890182]; CAS [KJCX2-YW-M15, KJCX2-YW-H18] |
| Department | LNM微纳米流体力学 |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/47122 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100190, Peoples R China. |
| Recommended Citation GB/T 7714 | Sun JS,Liu C,Li MM,et al. Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels[J]. BIOMICROFLUIDICS,2013,7,1,:011802/1-011802/11. |
| APA | Sun JS.,刘超.,Li MM.,Wang JD.,Xianyu YL.,...&Hu, GQ .(2013).Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels.BIOMICROFLUIDICS,7(1),011802/1-011802/11. |
| MLA | Sun JS,et al."Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels".BIOMICROFLUIDICS 7.1(2013):011802/1-011802/11. |
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