| Cooperative entry of nanoparticles into the cell | |
Wang JL(王九令) ; Yao HM(姚海民); Shi XH(施兴华)
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| Source Publication | Journal of The Mechanics and Physics of Solids
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| 2014 | |
| Volume | 73Pages:151-165 |
| ISSN | 0022-5096 |
| Abstract | Interaction of nanoparticles (NPs) with cell membrane is a crucial issue in studying drug delivery, photodynamic therapy system and cytotoxicity. Single NP with relatively small size cannot be fully wrapped by the cell membrane, which prohibits its uptake. One feasible way is cooperative entry, i.e., recruiting and assembling multiple small NPs to form a larger NP cluster to enter into a cell. In this work, we present theoretical analysis about the cooperative entry of multiple NPs. Through free energy calculation we investigate how the NPs׳ size, shape, interval and NP/cell interfacial binding energy influence the feasibility of entry. Interestingly we find that the cooperative entry of oblate ellipsoidal NPs can get larger energy compensation than individual ones as well as spherical ones. We also propose that soft NPs have preference in cooperative entry of the cell. Our work can be used to actively design and transfer NPs in applications such as drug delivery as well as to understand the shape effect on toxic mechanism of ellipsoidal NPs. |
| Keyword | Cellular Uptake Cooperative Entry Nanoparticles Spherical Buds |
| Subject Area | Solid Mechanics |
| URL | 查看原文 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000347023600011 |
| Funding Organization | NSFC Grants 11272327,11422215,11023001 |
| Department | LNM微结构计算力学（筹） |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/49359 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Shi XH(施兴华) |
| Recommended Citation GB/T 7714 | Wang JL,Yao HM,Shi XH. Cooperative entry of nanoparticles into the cell[J]. Journal of The Mechanics and Physics of Solids,2014,73:151-165. |
| APA | 王九令,姚海民,&施兴华.(2014).Cooperative entry of nanoparticles into the cell.Journal of The Mechanics and Physics of Solids,73,151-165. |
| MLA | 王九令,et al."Cooperative entry of nanoparticles into the cell".Journal of The Mechanics and Physics of Solids 73(2014):151-165. |
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