| Inertial focusing of spherical particles in rectangular microchannels over a wide range of Reynolds numbers | |
Liu C(刘超) ; Hu GQ(胡国庆); Jiang XY; Sun JS; Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
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| Source Publication | Lab on A Chip
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| 2015 | |
| Volume | 15Issue:4Pages:1168-1177 |
| ISSN | 1473-0197 |
| Abstract | Inertial microfluidics has emerged as an important tool for manipulating particles and cells. For a better design of inertial microfluidic devices, we conduct 3D direct numerical simulations (DNS) and experiments to determine the complicated dependence of focusing behaviour on the particle size, channel aspect ratio, and channel Reynolds number. We find that the well-known focusing of the particles at the two centers of the long channel walls occurs at a relatively low Reynolds number, whereas additional stable equilibrium positions emerge close to the short walls with increasing Reynolds number. Based on the numerically calculated trajectories of particles, we propose a two-stage particle migration which is consistent with experimental observations. We further present a general criterion to secure good focusing of particles for high flow rates. This work thus provides physical insight into the multiplex focusing of particles in rectangular microchannels with different geometries and Reynolds numbers, and paves the way for efficiently designing inertial microfluidic devices. |
| Subject Area | Biochemistry & Molecular Biology ; Chemistry ; Science & Technology - Other Topics |
| DOI | 10.1039/c4lc01216j |
| URL | 查看原文 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000349404200028 |
| Funding Organization | We thank the Ministry of Science and Technology (2011CB707604 and 2013AA032204) and the National Science Foundation of China (11272321, 21475028, and 51105086) for financial support. We sincerely thank Dr. William D. Henshaw for making the finite-difference code - overture available to us. The numerical simulations were performed on TianHe-1(A) at the National Supercomputing Center in Tianjin. |
| Department | LNM微纳米流体力学 |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/49627 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China. |
| Recommended Citation GB/T 7714 | Liu C,Hu GQ,Jiang XY,et al. Inertial focusing of spherical particles in rectangular microchannels over a wide range of Reynolds numbers[J]. Lab on A Chip,2015,15,4,:1168-1177. |
| APA | Liu C,Hu GQ,Jiang XY,Sun JS,&Hu, GQ .(2015).Inertial focusing of spherical particles in rectangular microchannels over a wide range of Reynolds numbers.Lab on A Chip,15(4),1168-1177. |
| MLA | Liu C,et al."Inertial focusing of spherical particles in rectangular microchannels over a wide range of Reynolds numbers".Lab on A Chip 15.4(2015):1168-1177. |
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| c4lc01216j.pdf（4112KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-ND | View Download | |
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