| Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film | |
Hu QL; Jiao B ; Shi XH(施兴华); Valle RP; Zuo YY; Hu GQ(胡国庆); Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
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| Source Publication | NANOSCALE
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| 2015 | |
| Volume | 7Issue:43Pages:18025-18029 |
| ISSN | 2040-3364 |
| Abstract | Graphene oxide (GO) is the most common derivative of graphene and has been used in a large range of biomedical applications. Despite considerable progress in understanding its cytotoxicity, its potential inhalation toxicity is still largely unknown. As the pulmonary surfactant (PS) film is the first line of host defense, interaction with the PS film determines the fate of the inhaled nanomaterials and their potential toxicity. Using a coarse-grained molecular dynamics model, we reported, for the first time, a novel mechanism of toxicity caused by the inhaled GO nanosheets. Upon deposition, the GO nanosheets induce pores in the PS film and thus have adverse effects on the ultrastructure and biophysical properties of the PS film. Notably, the pores induced by GO nanosheets result in increasing the compressibility of the PS film, which is an important indication of surfactant inhibition. In vitro experiments have also been conducted to study the interactions between GO and animal-derived natural PS films, qualitatively confirming the simulation results. |
| DOI | 10.1039/c5nr05401j |
| URL | 查看原文 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000364048900006 |
| WOS Keyword | NANOPARTICLES ; TOXICITY ; TRANSLOCATION ; NANOPLATELETS ; NANOMATERIALS ; CYTOTOXICITY ; SIMULATIONS ; INHIBITION ; MONOLAYER ; SYSTEM |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| Funding Organization | This work was financially supported by MOST 2011CB707604, NSFC 11272321 (G.H.), NSF Grant No. CBET-1236596 (Y.Y.Z.), and LNM Open Fund. The MD simulations were performed on TianHe-1(A) at the National Supercomputing Center in Tianjin. We thank Walter Klein at ONY Inc. for donation of Infasurf samples. |
| Department | LNM微纳米流体力学 |
| Classification | 一类 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/58389 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Hu, GQ (reprint author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China. |
| Recommended Citation GB/T 7714 | Hu QL,Jiao B,Shi XH,et al. Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film[J]. NANOSCALE,2015,7,43,:18025-18029. |
| APA | Hu QL.,Jiao B.,施兴华.,Valle RP.,Zuo YY.,...&Hu, GQ .(2015).Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film.NANOSCALE,7(43),18025-18029. |
| MLA | Hu QL,et al."Effects of graphene oxide nanosheets on the ultrastructure and biophysical properties of the pulmonary surfactant film".NANOSCALE 7.43(2015):18025-18029. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| J2015-035.pdf（1882KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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