| Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment | |
Wei JC(韦佳辰); Song F(宋凡) ; Song, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China.
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| Source Publication | INTERNATIONAL JOURNAL OF MODERN PHYSICS B
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| 2017-01-30 | |
| Volume | 31Issue:3 |
| ISSN | 0217-9792 |
| Abstract | Based on a very simple coarse-grained colloidal model here we implement an effective hard-sphere theory and numerical simulation to capture the general features of the association equilibria for globular proteins in crowded environment. We measure the activity coefficient i.e. the deviation from ideal behavior of protein solution and the crowding factor i.e. the contribution of crowders to the association equilibria for proteins in macromolecular crowding. The results show that the association balance in macro molecular crowding depends sensitively on the magnitude of protein-crowder attraction and the relative size of reactant to crowding agent. Since our coarse-grained model is irrelevant to the microscopic details of the molecules it can be applied to the control of the association equilibria of many globular proteins such as bovine serum albumin crystallin and lysozyme. |
| Keyword | Globular Protein Association Equilibria Short-range Attraction Macromolecular Crowding |
| DOI | 10.1142/S0217979217500072 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000395314300007 |
| WOS Keyword | BOVINE SERUM-ALBUMIN ; LIGHT-SCATTERING ; MODEL ; DEPENDENCE ; REPULSION ; SPHERES |
| WOS Research Area | Physics |
| WOS Subject | Physics, Applied ; Physics, Condensed Matter ; Physics, Mathematical |
| Funding Organization | National Natural Science Foundation of China(11232013 ; 11472285) |
| Department | LNM生物材料微结构和力学性能 |
| Classification | Q4 |
| Ranking | 1 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/60591 |
| Collection | 非线性力学国家重点实验室 |
| Corresponding Author | Song, F (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech LNM, Beijing 100190, Peoples R China. |
| Recommended Citation GB/T 7714 | Wei JC,Song F,Song, F . Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment[J]. INTERNATIONAL JOURNAL OF MODERN PHYSICS B,2017,31,3,. |
| APA | 韦佳辰,宋凡,&Song, F .(2017).Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment.INTERNATIONAL JOURNAL OF MODERN PHYSICS B,31(3). |
| MLA | 韦佳辰,et al."Association equilibria for proteins interacted with crowders of short-range attraction in crowded environment".INTERNATIONAL JOURNAL OF MODERN PHYSICS B 31.3(2017). |
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| JouAr-2017-033.pdf（1734KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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