The effective utilization of reserves in tight sandstone reservoirs is one of the major concerns in terms of the development of tight sandstone gas reservoirs. However, the characteristics of reserve utilization are not fully understood, and many uncertainties still exist in the process. For this purpose, long cores on the Su 6 block of Sulige tight sandstone gas field in China were selected, and a multipoint embedded measurement system was established to study the characteristics of effective reserve utilization. Then, the effects of the related reservoir properties and production parameters were investigated. Based on the similarity theory, the effective conversion relationship between the physical experiment and the actual field production was established. The results showed that the pressure distribution in the exploitation of tight gas reservoir is nonlinear, and water cut in the reservoir will hinder the effective utilization of reserves. The lower the reservoir permeability, the larger the negative effect of water on reservoir utilization. Lower gas production rate and higher original pressure are associated with a smoother drawdown curve, which results in larger reserve utilization. The moving boundary expands with time, and its initial propagation velocity increase and then decrease. Additionally, the water cut in the reservoir can delay the spread of moving boundary propagation. The experimental results are consistent with the actual results of the field production by the similarity criterion, which can reflect and predict the production performance in tight gas reservoirs effectively. These results can provide a better understanding of reservoir pressure distribution and effective utilization of reserves to optimize the gas recovery and development benefit in tight sandstone gas reservoirs.