| Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli | |
Shu XY(舒芯钰)1,2,3; Li N(李宁)1,2,3 ; Wu Y(武亿)1,2,3; Li W(李旺)1,2,3; Zhang XY(张晓宇)1,2,3; Li PW(李培文)1,2; Lv DY(吕东媛)1,2,3; Lv SQ(吕守芹)1,2,3; Long M(龙勉)1,2,3
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| Corresponding Author | Li, Ning([email protected]) ; Long, Mian([email protected]) |
| Source Publication | ACTA MECHANICA SINICA
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| 2021-03-10 | |
| Pages | 17 |
| ISSN | 0567-7718 |
| Abstract | Liver sinusoidal endothelial cells (LSECs) are the gatekeeper of liver to maintain hepatic homeostasis. They are formed into the highly specialized endothelium between vascular lumen and the space of Disse and are mechanosensitive to respond varied microenvironments. Shear stress and mechanical stretch induced by blood perfusion and substrate stiffness enhancement derived from deposition of extracellular matrix (ECM) are major mechanical stimuli that surround LSECs. This review introduces how LSECs respond to the external forces in both physiological and pathological cases and what is the interplay of LSECs with other hepatic cells. Molecular mechanisms that potentiate LSECs mechanotransduction are also discussed. |
| Keyword | Liver sinusoidal endothelial cell Shear stress Mechanical stretch Extracellular matrix Stiffness |
| DOI | 10.1007/s10409-021-01057-3 |
| Indexed By | SCI ; EI ; CSCD |
| Language | 英语 |
| WOS ID | WOS:000627222700002 |
| WOS Research Area | Engineering ; Mechanics |
| WOS Subject | Engineering, Mechanical ; Mechanics |
| Funding Project | National Natural Science Foundation of China[91642203] ; National Natural Science Foundation of China[31627804] ; National Natural Science Foundation of China[31870930] ; Scientific Instrument Developing Project ; Strategic Priority Research Program ; Frontier Science Key Project of Chinese Academy of Sciences[GJJSTU20190005] ; Frontier Science Key Project of Chinese Academy of Sciences[QYZDJ-SSW-JSC018] ; Frontier Science Key Project of Chinese Academy of Sciences[XDB22040101] |
| Funding Organization | National Natural Science Foundation of China ; Scientific Instrument Developing Project ; Strategic Priority Research Program ; Frontier Science Key Project of Chinese Academy of Sciences |
| Classification | 二类 |
| Ranking | 1 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/86294 |
| Collection | 微重力重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Ctr Biomech & Bioengn, Key Lab Micrograv, Natl Micrograv Lab, Beijing 100190, Peoples R China; 2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; 3.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Shu XY,Li N,Wu Y,et al. Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli[J]. ACTA MECHANICA SINICA,2021:17. |
| APA | 舒芯钰.,李宁.,武亿.,李旺.,张晓宇.,...&龙勉.(2021).Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli.ACTA MECHANICA SINICA,17. |
| MLA | 舒芯钰,et al."Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli".ACTA MECHANICA SINICA (2021):17. |
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| File Name/Size | DocType | Version | Access | License | ||
| Jp2021163.pdf（1359KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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