| Topological Constraints with Optimal Length Promote the Formation of Chromosomal Territories at Weakened Degree of Phase Separation | |
Wei JC(韦佳辰)3,4,6; Tian, Hao1,2; Zhou, Rui1; Shao YF(邵颖峰)3,4,5 ; Song F(宋凡)3,4,5; Gao, Yi Qin1,2,6
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| Corresponding Author | Wei, Jiachen([email protected]) ; Gao, Yi Qin([email protected]) |
| Source Publication | JOURNAL OF PHYSICAL CHEMISTRY B
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| 2021-08-19 | |
| Volume | 125Issue:32Pages:9092-9101 |
| ISSN | 1520-6106 |
| Abstract | It is generally agreed that the nuclei of eukaryotic cells at interphase are partitioned into disjointed territories, with distinct regions occupied by certain chromosomes. However, the underlying mechanism for such territorialization is still under debate. Here we model chromosomes as coarse-grained block copolymers and to investigate the effect of loop domains (LDs) on the formation of compartments and territories based on dissipative particle dynamics. A critical length of LDs, which depends sensitively on the length of polymeric blocks, is obtained to minimize the degree of phase separation. This also applies to the two-polymer system: The critical length not only maximizes the degree of territorialization but also minimizes the degree of phase separation. Interestingly, by comparing with experimental data, we find the critical length for LDs and the corresponding length of blocks to be respectively very close to the mean length of topologically associating domains (TADs) and chromosomal segments with different densities of CpG islands for human chromosomes. The results indicate that topological constraints with optimal length can contribute to the formation of territories by weakening the degree of phase separation, which likely promotes the chromosomal flexibility in response to genetic regulations. |
| DOI | 10.1021/acs.jpcb.1c03523 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000687835300005 |
| WOS Keyword | RANDOM COPOLYMERS ; CHROMATIN ; MECHANISMS ; GENOME ; ORGANIZATION ; PRINCIPLES ; DYNAMICS ; DOMAINS ; REGIONS |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Physical |
| Funding Project | NSFC Basic Science Center Program for Multiscale Problems in Nonlinear Mechanics[11988102] ; National Natural Science Foundation of China[92053202] ; National Natural Science Foundation of China[22050003] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB22040102] |
| Funding Organization | NSFC Basic Science Center Program for Multiscale Problems in Nonlinear Mechanics ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| Classification | Q3 |
| Ranking | 1 |
| Contributor | Wei, Jiachen ; Gao, Yi Qin |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/87354 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Biomed Pioneering Innovat Ctr BIOPIC, Beijing 100871, Peoples R China; 2.Peking Univ, Beijing Adv Innovat Ctr Genom ICG, Beijing 100871, Peoples R China; 3.Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; 4.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing 100190, Peoples R China; 5.Univ Chinese Acad Sci, Sch Engn Sci, Beijing 100049, Peoples R China; 6.Shenzhen Bay Lab, Shenzhen 518055, Guangdong, Peoples R China |
| Recommended Citation GB/T 7714 | Wei JC,Tian, Hao,Zhou, Rui,et al. Topological Constraints with Optimal Length Promote the Formation of Chromosomal Territories at Weakened Degree of Phase Separation[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2021,125,32,:9092-9101.Rp_Au:Wei, Jiachen, Gao, Yi Qin |
| APA | 韦佳辰,Tian, Hao,Zhou, Rui,邵颖峰,宋凡,&Gao, Yi Qin.(2021).Topological Constraints with Optimal Length Promote the Formation of Chromosomal Territories at Weakened Degree of Phase Separation.JOURNAL OF PHYSICAL CHEMISTRY B,125(32),9092-9101. |
| MLA | 韦佳辰,et al."Topological Constraints with Optimal Length Promote the Formation of Chromosomal Territories at Weakened Degree of Phase Separation".JOURNAL OF PHYSICAL CHEMISTRY B 125.32(2021):9092-9101. |
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| Jp2021F432.pdf（7459KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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