Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control

doi:10.3390/mi13050774

IMECH-IR > 流固耦合系统力学重点实验室

	Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control
	Ling BW(凌博闻)1,2; Battiato, Ilenia 1
通讯作者	Battiato, Ilenia([email protected])
发表期刊	MICROMACHINES
	2022-05-01
卷号	13 期号:5 页码:8
摘要	Generating the desired solute concentration signal in micro-environments is vital to many applications ranging from micromixing to analyzing cellular response to a dynamic microenvironment. We propose a new modular design to generate targeted temporally varying concentration signals in microfluidic systems while minimizing perturbations to the flow field. The modularized design, here referred to as module-fluidics, similar in principle to interlocking toy bricks, is constructed from a combination of two building blocks and allows one to achieve versatility and flexibility in dynamically controlling input concentration. The building blocks are an oscillator and an integrator, and their combination enables the creation of controlled and complex concentration signals, with different user-defined time-scales. We show two basic connection patterns, in-series and in-parallel, to test the generation, integration, sampling and superposition of temporally-varying signals. All such signals can be fully characterized by analytic functions, in analogy with electric circuits, and allow one to perform design and optimization before fabrication. Such modularization offers a versatile and promising platform that allows one to create highly customizable time-dependent concentration inputs which can be targeted to the specific application of interest.
关键词	mircofluidics micromodel microfluidic valve
DOI	10.3390/mi13050774
收录类别	SCI ; EI
语种	英语
WOS记录号	WOS:000803291200001
关键词[WOS]	MICROMIXERS ; COMPLEX
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation ; Physics
WOS类目	Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation ; Physics, Applied
资助项目	Department of Energy[DE-SC0014227]
项目资助者	Department of Energy
论文分区	二类
力学所作者排名	1
RpAuthor	Battiato, Ilenia
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://dspace.imech.ac.cn/handle/311007/89526
专题	流固耦合系统力学重点实验室
作者单位	1.Stanford Univ, Energy Resource Engn, Stanford, CA 94305 USA; 2.Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Ling BW,Battiato, Ilenia. Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control[J]. MICROMACHINES,2022,13,5,:8.Rp_Au:Battiato, Ilenia
APA	凌博闻,&Battiato, Ilenia.(2022).Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control.MICROMACHINES,13(5),8.
MLA	凌博闻,et al."Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control".MICROMACHINES 13.5(2022):8.

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