| Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control | |
| Ling BW(凌博闻)1,2; Battiato, Ilenia1 | |
| Corresponding Author | Battiato, Ilenia([email protected]) |
| Source Publication | MICROMACHINES
 |
| 2022-05-01 | |
| Volume | 13Issue:5Pages:8 |
| Abstract | Generating the desired solute concentration signal in micro-environments is vital to many applications ranging from micromixing to analyzing cellular response to a dynamic microenvironment. We propose a new modular design to generate targeted temporally varying concentration signals in microfluidic systems while minimizing perturbations to the flow field. The modularized design, here referred to as module-fluidics, similar in principle to interlocking toy bricks, is constructed from a combination of two building blocks and allows one to achieve versatility and flexibility in dynamically controlling input concentration. The building blocks are an oscillator and an integrator, and their combination enables the creation of controlled and complex concentration signals, with different user-defined time-scales. We show two basic connection patterns, in-series and in-parallel, to test the generation, integration, sampling and superposition of temporally-varying signals. All such signals can be fully characterized by analytic functions, in analogy with electric circuits, and allow one to perform design and optimization before fabrication. Such modularization offers a versatile and promising platform that allows one to create highly customizable time-dependent concentration inputs which can be targeted to the specific application of interest. |
| Keyword | mircofluidics micromodel microfluidic valve |
| DOI | 10.3390/mi13050774 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000803291200001 |
| WOS Keyword | MICROMIXERS ; COMPLEX |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Instruments & Instrumentation ; Physics |
| WOS Subject | Chemistry, Analytical ; Nanoscience & Nanotechnology ; Instruments & Instrumentation ; Physics, Applied |
| Funding Project | Department of Energy[DE-SC0014227] |
| Funding Organization | Department of Energy |
| Classification | 二类 |
| Ranking | 1 |
| Contributor | Battiato, Ilenia |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/89526 |
| Collection | 流固耦合系统力学重点实验室 |
| Affiliation | 1.Stanford Univ, Energy Resource Engn, Stanford, CA 94305 USA; 2.Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Ling BW,Battiato, Ilenia. Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control[J]. MICROMACHINES,2022,13,5,:8.Rp_Au:Battiato, Ilenia |
| APA | 凌博闻,&Battiato, Ilenia.(2022).Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control.MICROMACHINES,13(5),8. |
| MLA | 凌博闻,et al."Module-Fluidics: Building Blocks for Spatio-Temporal Microenvironment Control".MICROMACHINES 13.5(2022):8. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Jp2022FA403_2022_Mod（2086KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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