This study aimed to reveal the anisotropic permeabilities of tight oil reservoirs impacted by heterogeneous minerals. SEM imaging, image processing, fractal calculation, microscopic reservoir modeling, and visual flow simulation were carried out to investigate the above problems. Results show that the variation coefficient of two-dimensional permeability for the studied tight reservoir samples ranges from 0.09 to 0.95, with an average value of 0.68. The penetration coefficient ranges from 1.16 to 2.64, with an average value of 2.13. The ratio of maximum to minimum permeability is between 1.25 and 7.67, with an average value of 5.62. The fluid flow in tight reservoirs has significant anisotropy comprising dominant flow through conductive channels. Flow in tight oil reservoirs tends to involve minor hydraulic fracturing with no proppant.