| Insights into intercellular receptor-ligand binding kinetics in cell communication | |
An, Chenyi1,6; Wang, Xiaohuan2; Song F(宋凡) ; Hu, Jinglei5,8; Li L(李龙)
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| Source Publication | FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
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| 2022-06 | |
| Volume | 10Pages:953353 |
| ISSN | 2296-4185 |
| Abstract | Cell-cell communication is crucial for cells to sense, respond and adapt to environmental cues and stimuli. The intercellular communication process, which involves multiple length scales, is mediated by the specific binding of membrane-anchored receptors and ligands. Gaining insight into two-dimensional receptor-ligand binding kinetics is of great significance for understanding numerous physiological and pathological processes, and stimulating new strategies in drug design and discovery. To this end, extensive studies have been performed to illuminate the underlying mechanisms that control intercellular receptor-ligand binding kinetics via experiment, theoretical analysis and numerical simulation. It has been well established that the cellular microenvironment where the receptor-ligand interaction occurs plays a vital role. In this review, we focus on the advances regarding the regulatory effects of three factors including 1) protein-membrane interaction, 2) biomechanical force, and 3) bioelectric microenvironment to summarize the relevant experimental observations, underlying mechanisms, as well as their biomedical significances and applications. Meanwhile, we introduce modeling methods together with experiment technologies developed for dealing with issues at different scales. We also outline future directions to advance the field and highlight that building up systematic understandings for the coupling effects of these regulatory factors can greatly help pharmaceutical development. |
| Keyword | cell communication intercellular receptor-ligand binding kinetics protein-membrane interaction biomechanical force bioelectric microenvironment |
| Subject Area | Biotechnology & Applied Microbiology ; Multidisciplinary Sciences |
| DOI | 10.3389/fbioe.2022.953353 |
| Indexed By | SCI ; EI |
| Language | 英语 |
| WOS ID | WOS:000823655300001 |
| Funding Organization | National Natural Science Foundation of China [11902327, 11972041, 12102389, 22161132012, 21973040] ; Youth In11ation Promotion Association CAS, China Postdoctoral Science Foundation [2020M681834] |
| Classification | 二类/Q1 |
| Ranking | 1 |
| Contributor | 李龙 ; Hu Jinglei |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://dspace.imech.ac.cn/handle/311007/90166 |
| Collection | 非线性力学国家重点实验室 |
| Affiliation | 1.Guizhou Med Univ, Sch Biol & Engn, Guiyang, Peoples R China 2.Zhejiang Univ, Sch Med, Dept Cell Biol, Hangzhou, Peoples R China 3.Peking Univ Third Hosp, Dept Rehabil Med, Beijing, Peoples R China 4.Chinese Acad Sci, State Key Lab Nonlinear Mech, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China 6.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China 7.Zhejiang Univ, Sch Med, Dept Cardiol, Affiliated Hosp 2, Hangzhou, Peoples R China 8.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China 9.Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China |
| Recommended Citation GB/T 7714 | An, Chenyi,Wang, Xiaohuan,Song F,et al. Insights into intercellular receptor-ligand binding kinetics in cell communication[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2022,10:953353.Rp_Au:李龙, Hu Jinglei |
| APA | An, Chenyi,Wang, Xiaohuan,宋凡,Hu, Jinglei,&李龙.(2022).Insights into intercellular receptor-ligand binding kinetics in cell communication.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,10,953353. |
| MLA | An, Chenyi,et al."Insights into intercellular receptor-ligand binding kinetics in cell communication".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10(2022):953353. |
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| Jp2022FA336_2022_Ins（1265KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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